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@ARTICLE{Dahmen:851339,
      author       = {Dahmen, Brigitte and Puetz, Vanessa B. and Scharke,
                      Wolfgang and von Polier, Georg G. and Herpertz-Dahlmann,
                      Beate and Konrad, Kerstin},
      title        = {{E}ffects of {E}arly-{L}ife {A}dversity on {H}ippocampal
                      {S}tructures and {A}ssociated {HPA} {A}xis {F}unctions},
      journal      = {Developmental neuroscience},
      volume       = {40},
      number       = {1},
      issn         = {1421-9859},
      address      = {Basel},
      publisher    = {Karger},
      reportid     = {FZJ-2018-05024},
      pages        = {13 - 22},
      year         = {2018},
      abstract     = {Early-life adversity (ELA) is one of the major risk factors
                      for serious mental and physical health risks later in life.
                      ELA has been associated with dysfunctional neurodevelopment,
                      especially in brain structures such as the hippocampus, and
                      with dysfunction of the stress system, including the
                      hypothalamic-pituitary-adrenal (HPA) axis. Children who have
                      experienced ELA are also more likely to suffer from mental
                      health disorders such as depression later in life. The exact
                      interplay of aberrant neurodevelopment and HPA axis
                      dysfunction as risks for psychopathology is not yet clear.
                      We investigated volume differences in the bilateral
                      hippocampus and in stress-sensitive hippocampal subfields,
                      behavior problems, and diurnal cortisol activity in 24
                      children who had experienced documented ELA (including
                      out-of-home placement) in a circumscribed duration of
                      adversity only in their first 3 years of life in comparison
                      to data on 25 control children raised by their biological
                      parents. Hippocampal volumes and stress-sensitive
                      hippocampal subfields (Cornu ammonis [CA]1, CA3, and the
                      granule-cell layer of the dentate gyrus [GCL-DG]) were
                      significantly smaller in children who had experienced ELA,
                      taking psychiatric diagnoses and dimensional
                      psychopathological symptoms into account. ELA moderated the
                      relationship between left hippocampal volume and cortisol:
                      in the control group, hippocampal volumes were not related
                      to diurnal cortisol, while in ELA children, a positive
                      linear relationship between left hippocampal volume and
                      diurnal cortisol was present. Our findings show that ELA is
                      associated with altered development of the hippocampus, and
                      an altered relationship between hippocampal volume and HPA
                      axis activity in youth in care, even after they have lived
                      in stable and caring foster family environments for years.
                      Altered hippocampal development after ELA could thus be
                      associated with a risk phenotype for the development of
                      psychiatric disorders later in life.},
      cin          = {INM-3 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29237154},
      UT           = {WOS:000428954300002},
      doi          = {10.1159/000484238},
      url          = {https://juser.fz-juelich.de/record/851339},
}