%0 Journal Article
%A Lohmann, Philipp
%A Kocher, Martin
%A Ceccon, Garry
%A Bauer, Elena K.
%A Stoffels, Gabriele
%A Viswanathan, Shivakumar
%A Ruge, Maximilian I.
%A Neumaier, Bernd
%A Shah, Nadim J.
%A Fink, Gereon R.
%A Langen, Karl-Josef
%A Galldiks, Norbert
%T Combined FET PET/MRI radiomics differentiates radiation injury from recurrent brain metastasis
%J NeuroImage: Clinical
%V 20
%@ 2213-1582
%C [Amsterdam u.a.]
%I Elsevier
%M FZJ-2018-05053
%P 537 - 542
%D 2018
%X Background<br>The aim of this study was to investigate the potential of combined textural feature analysis of contrast-enhanced MRI (CE-MRI) and static O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET for the differentiation between local recurrent brain metastasis and radiation injury since CE-MRI often remains inconclusive.<br>Methods<br>Fifty-two patients with new or progressive contrast-enhancing brain lesions on MRI after radiotherapy (predominantly stereotactic radiosurgery) of brain metastases were additionally investigated using FET PET. Based on histology (n = 19) or clinicoradiological follow-up (n = 33), local recurrent brain metastases were diagnosed in 21 patients (40%) and radiation injury in 31 patients (60%). Forty-two textural features were calculated on both unfiltered and filtered CE-MRI and summed FET PET images (20–40 min p.i.), using the software LIFEx. After feature selection, logistic regression models using a maximum of five features to avoid overfitting were calculated for each imaging modality separately and for the combined FET PET/MRI features. The resulting models were validated using cross-validation. Diagnostic accuracies were calculated for each imaging modality separately as well as for the combined model.<br>Results<br>For the differentiation between radiation injury and recurrence of brain metastasis, textural features extracted from CE-MRI had a diagnostic accuracy of 81% (sensitivity, 67%; specificity, 90%). FET PET textural features revealed a slightly higher diagnostic accuracy of 83% (sensitivity, 88%; specificity, 75%). However, the highest diagnostic accuracy was obtained when combining CE-MRI and FET PET features (accuracy, 89%; sensitivity, 85%; specificity, 96%).<br>Conclusions<br>Our findings suggest that combined FET PET/CE-MRI radiomics using textural feature analysis offers a great potential to contribute significantly to the management of patients with brain metastases.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30175040
%U <Go to ISI:>//WOS:000450799000058
%R 10.1016/j.nicl.2018.08.024
%U https://juser.fz-juelich.de/record/851404