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@ARTICLE{Gelissen:851479,
      author       = {Gelissen, Arjan P. H. and Scotti, Andrea and Turnhoff,
                      Sarah K. and Janssen, Corinna and Radulescu, Aurel and Pich,
                      Andrij and Rudov, Andrey A. and Potemkin, Igor I. and
                      Richtering, Walter},
      title        = {{A}n anionic shell shields a cationic core allowing for
                      uptake and release of polyelectrolytes within core–shell
                      responsive microgels},
      journal      = {Soft matter},
      volume       = {14},
      number       = {21},
      issn         = {1744-6848},
      address      = {London},
      publisher    = {Royal Soc. of Chemistry},
      reportid     = {FZJ-2018-05115},
      pages        = {4287 - 4299},
      year         = {2018},
      abstract     = {To realize carriers for drug delivery, cationic containers
                      are required for anionic guests. Nevertheless, the toxicity
                      of cationic carriers limits their practical use. In this
                      study, we investigate a model system of polyampholyte
                      N-isopropylacrylamide (NIPAM)-based microgels with a
                      cationic core and an anionic shell to study whether the
                      presence of a negative shell allows the cationic core to be
                      shielded while still enabling the uptake and release of the
                      anionic guest polyelectrolytes. These microgels are loaded
                      with polystyrene sulfonate of different molecular weights to
                      investigate the influence of their chain length on the
                      uptake and release process. By means of small-angle neutron
                      scattering, we evaluate the spatial distribution of
                      polystyrene sulfonate within the microgels. The guest
                      molecules are located in different parts of the core–shell
                      microgels depending on their size. By combining these
                      scattering results with UV-vis spectroscopy, electrophoretic
                      mobility and potentiometric titrations we gain complementary
                      results to investigate the uptake and release process of
                      polyelectrolytes in polyampholyte core–shell microgels.
                      Moreover, Brownian molecular dynamic simulations are
                      performed to compare the experimental and theoretical
                      results of this model. Our findings demonstrate that the
                      presence of a shell still enables efficient uptake of guest
                      molecules into the cationic core. These anionic guest
                      molecules can be released through an anionic shell.
                      Furthermore, the presence of a shell enhances the stability
                      of the microgel–polyelectrolyte complexes with respect to
                      the cationic precursor microgel alone.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29774926},
      UT           = {WOS:000434244800007},
      doi          = {10.1039/C8SM00397A},
      url          = {https://juser.fz-juelich.de/record/851479},
}