TY  - JOUR
AU  - Papagiannopoulos, Aristeidis
AU  - Vlassi, Eleni
AU  - Pispas, Stergios
AU  - Houston, Judith
TI  - Association and Internal Morphology of Self-Assembled HPPhOx/BSA Hybrid Nanoparticles in Aqueous Solutions
JO  - The journal of physical chemistry  / B
VL  - 122
IS  - 29
SN  - 1520-5207
CY  - Washington, DC
PB  - Soc.
M1  - FZJ-2018-05116
SP  - 7426 - 7435
PY  - 2018
AB  - We investigate the formation of hybrid polyelectrolyte/protein nanoparticles by associations between aggregates of partially hydrolyzed poly(2-phenyl-2-oxazoline) (HPPhOx) and bovine serum albumin (BSA) in aqueous solutions. Light scattering experiments show that at conditions of low salt, BSA creates interaggregate bridges and increases the size of the HPPhOx nanoparticles. At high salt contents, breaking of aggregates leads to well-defined nanoparticles. The interior of the formed nanoparticles is probed by small-angle neutron scattering. At low salt, diffuse arrangements are observed, whereas at high salt concentration, scattering is dominated by well-defined hydrophobic domains enhanced by the incorporation of BSA. This system shows that the combination of hydrophobic and electrostatic interactions in random-amphiphilic-polyelectrolyte/protein complexes can be used to determine the properties of self-assembled hybrid multifunctional nanoparticles.
LB  - PUB:(DE-HGF)16
C6  - pmid:29947516
UR  - <Go to ISI:>//WOS:000440519900023
DO  - DOI:10.1021/acs.jpcb.8b04364
UR  - https://juser.fz-juelich.de/record/851480
ER  -