000851757 001__ 851757
000851757 005__ 20220930130157.0
000851757 0247_ $$2doi$$a10.3233/RNN-180815
000851757 0247_ $$2Handle$$a2128/20231
000851757 0247_ $$2pmid$$apmid:30282379
000851757 0247_ $$2WOS$$aWOS:000451336100001
000851757 037__ $$aFZJ-2018-05281
000851757 082__ $$a610
000851757 1001_ $$0P:(DE-Juel1)165846$$aKusch, M.$$b0
000851757 245__ $$aRecovery from apraxic deficits and its neural correlate
000851757 260__ $$aAmsterdam$$bIOS Press$$c2018
000851757 3367_ $$2DRIVER$$aarticle
000851757 3367_ $$2DataCite$$aOutput Types/Journal article
000851757 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1543494353_22948
000851757 3367_ $$2BibTeX$$aARTICLE
000851757 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000851757 3367_ $$00$$2EndNote$$aJournal Article
000851757 520__ $$aBackground and Objective: Apraxia is a deficit of motor cognition leading to difficulties in actual tool use, imitation of gestures, and pantomiming object use. To date, little data exist regarding the recovery from apraxic deficits after stroke, and no statistical lesion mapping study investigated the neural correlate of recovery from apraxia. Accordingly, we here examined recovery from apraxic deficits, differential associations of apraxia task (imitation vs. pantomime) and effector (bucco-facial vs. limb apraxia) with recovery, and the underlying neural correlates. Methods: We assessed apraxia in 39 patients with left hemisphere (LH) stroke both at admission and approximately 11 days later. Furthermore, we collected clinical imaging data to identify brain regions associated with recovery from apraxic deficits using voxel-based lesion-symptom mapping (VLSM). Results:Between the two assessments, a significant recovery from apraxic deficits was observed with a tendency of enhanced recovery of limb compared to bucco-facial apraxia. VLSM analyses revealed that within the lesion pattern initially associated with apraxia, lesions of the left insula were associated with remission of apraxic deficits, whereas lesions to the (inferior) parietal lobe (IPL; supramarginal and angular gyrus) and the superior longitudinal fasciculus (SLF) were associated with persistent apraxic deficits. Conclusions: Data suggest that lesions affecting the core regions (and white matter) of the fronto-parietal network cause more persistent apraxic deficits than lesions affecting other regions (here: the left insula) that also contribute to motor cognition and apraxic deficits.
000851757 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000851757 588__ $$aDataset connected to CrossRef
000851757 7001_ $$0P:(DE-Juel1)169625$$aSchmidt, Claudia$$b1$$eCorresponding author
000851757 7001_ $$0P:(DE-HGF)0$$aGöden, L.$$b2
000851757 7001_ $$0P:(DE-Juel1)171739$$aTscherpel, C.$$b3
000851757 7001_ $$0P:(DE-HGF)0$$aStahl, J.$$b4
000851757 7001_ $$0P:(DE-HGF)0$$aSaliger, J.$$b5
000851757 7001_ $$0P:(DE-HGF)0$$aKarbe, H.$$b6
000851757 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b7
000851757 7001_ $$0P:(DE-HGF)0$$aWeiss, P. H.$$b8
000851757 773__ $$0PERI:(DE-600)2007771-3$$a10.3233/RNN-180815$$gp. 1 - 10$$n6$$p669–678$$tRestorative neurology and neuroscience$$v36$$x0922-6028$$y2018
000851757 8564_ $$uhttps://juser.fz-juelich.de/record/851757/files/20180912164559718.pdf
000851757 8564_ $$uhttps://juser.fz-juelich.de/record/851757/files/rnn%252F2018%252F36-6%252Frnn-36-6-rnn180815%252Frnn-36-rnn180815.pdf$$yRestricted
000851757 8564_ $$uhttps://juser.fz-juelich.de/record/851757/files/20180912164559718.pdf?subformat=pdfa$$xpdfa
000851757 8564_ $$uhttps://juser.fz-juelich.de/record/851757/files/Kusch_2018_Postprint_Restorative%20Neurology%20and%20Neuroscience_Recovery%20from%20apraxic%20deficits%20and%20its%20neural%20correlate.pdf$$yOpenAccess
000851757 8564_ $$uhttps://juser.fz-juelich.de/record/851757/files/rnn%252F2018%252F36-6%252Frnn-36-6-rnn180815%252Frnn-36-rnn180815.pdf?subformat=pdfa$$xpdfa$$yRestricted
000851757 8564_ $$uhttps://juser.fz-juelich.de/record/851757/files/Kusch_2018_Postprint_Restorative%20Neurology%20and%20Neuroscience_Recovery%20from%20apraxic%20deficits%20and%20its%20neural%20correlate.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000851757 8767_ $$8P20181765$$92018-09-07$$d2018-09-12$$ePublication charges$$jZahlung erfolgt
000851757 8767_ $$8P20181765$$92018-09-12$$d2018-09-12$$eReprint$$jZahlung erfolgt
000851757 909CO $$ooai:juser.fz-juelich.de:851757$$popenCost$$pVDB$$pdriver$$pOpenAPC$$popen_access$$popenaire$$pdnbdelivery
000851757 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)165846$$aForschungszentrum Jülich$$b0$$kFZJ
000851757 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)169625$$aForschungszentrum Jülich$$b1$$kFZJ
000851757 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)171739$$aForschungszentrum Jülich$$b3$$kFZJ
000851757 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b7$$kFZJ
000851757 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-HGF)0$$aForschungszentrum Jülich$$b8$$kFZJ
000851757 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000851757 9141_ $$y2018
000851757 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000851757 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000851757 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bRESTOR NEUROL NEUROS : 2015
000851757 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000851757 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000851757 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000851757 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000851757 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000851757 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000851757 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000851757 920__ $$lyes
000851757 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000851757 980__ $$ajournal
000851757 980__ $$aVDB
000851757 980__ $$aUNRESTRICTED
000851757 980__ $$aI:(DE-Juel1)INM-3-20090406
000851757 980__ $$aAPC
000851757 9801_ $$aAPC
000851757 9801_ $$aFullTexts