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@ARTICLE{Elmenhorst:851820,
      author       = {Elmenhorst, Eva-Maria and Elmenhorst, David and Benderoth,
                      Sibylle and Kroll, Tina and Bauer, Andreas and Aeschbach,
                      Daniel},
      title        = {{C}ognitive impairments by alcohol and sleep deprivation
                      indicate trait characteristics and a potential role for
                      adenosine {A} 1 receptors},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {115},
      number       = {31},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2018-05320},
      pages        = {8009 - 8014},
      year         = {2018},
      abstract     = {Trait-like differences in cognitive performance after sleep
                      loss put some individuals more at risk than others, the
                      basis of such disparities remaining largely unknown.
                      Similarly, interindividual differences in impairment in
                      response to alcohol intake have been observed. We tested
                      whether performance impairments due to either acute or
                      chronic sleep loss can be predicted by an individual’s
                      vulnerability to acute alcohol intake. Also, we used
                      positron emission tomography (PET) to test whether acute
                      alcohol infusion results in an up-regulation of cerebral A1
                      adenosine receptors (A1ARs), similar to the changes
                      previously observed following sleep deprivation. Sustained
                      attention in the psychomotor vigilance task (PVT) was tested
                      in 49 healthy volunteers (26 ± 5 SD years; 15 females) (i)
                      under baseline conditions: (ii) after ethanol intake, and
                      after either (iii) total sleep deprivation (TSD; 35 hours
                      awake; n = 35) or (iv) partial sleep deprivation (PSD; four
                      nights with 5 hours scheduled sleep; n = 14). Ethanol-
                      versus placebo-induced changes in cerebral A1AR availability
                      were measured in 10 healthy male volunteers (31 ± 9 years)
                      with [18F]8-cyclopentyl-3-(3-fluoropropyl)-1-propylxanthine
                      (CPFPX) PET. Highly significant correlations between the
                      performance impairments induced by ethanol and sleep
                      deprivation were found for various PVT parameters, including
                      mean speed (TSD, r = 0.62; PSD, r = 0.84). A1AR availability
                      increased up to $26\%$ in several brain regions with ethanol
                      infusion. Our studies revealed individual trait
                      characteristics for being either vulnerable or resilient to
                      both alcohol and to sleep deprivation. Both interventions
                      induce gradual increases in cerebral A1AR availability,
                      pointing to a potential common molecular response
                      mechanism.},
      cin          = {INM-2},
      ddc          = {000},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30012607},
      UT           = {WOS:000440285800056},
      doi          = {10.1073/pnas.1803770115},
      url          = {https://juser.fz-juelich.de/record/851820},
}