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@ARTICLE{Lohmann:852419,
      author       = {Lohmann, Philipp and Piroth, Marc D. and Sellhaus, Bernd
                      and Weis, Joachim and Geisler, Stefanie and Oros-Peusquens,
                      Ana-Maria and Mohlberg, Hartmut and Amunts, Katrin and Shah,
                      Nadim J. and Galldiks, Norbert and Langen, Karl-Josef},
      title        = {{C}orrelation of {D}ynamic
                      {O}-(2-[18{F}]{F}luoroethyl)-{L}-{T}yrosine {P}ositron
                      {E}mission {T}omography, {C}onventional {M}agnetic
                      {R}esonance {I}maging, and {W}hole-{B}rain {H}istopathology
                      in a {P}retreated {G}lioblastoma: {A} {P}ostmortem {S}tudy},
      journal      = {World neurosurgery},
      volume       = {119},
      issn         = {1878-8750},
      address      = {Amsterdam},
      publisher    = {Elsevier},
      reportid     = {FZJ-2018-05373},
      pages        = {e653-e660},
      year         = {2018},
      abstract     = {ObjectiveAmino acid positron emission tomography (PET)
                      using O-(2-[18F]fluoroethyl)-L-tyrosine (FET) provides
                      important additional information on the extent of viable
                      tumor tissue of glioblastoma compared with magnetic
                      resonance imaging (MRI). Especially after radiochemotherapy,
                      progression of contrast enhancement in MRI is equivocal and
                      may represent either tumor progression or treatment-related
                      changes. Here, the first case comparing postmortem
                      whole-brain histology of a patient with pretreated
                      glioblastoma with dynamic in vivo FET PET and MRI is
                      presented.MethodsA 61-year-old patient with glioblastoma
                      initially underwent partial tumor resection and died 11
                      weeks after completion of chemoradiation with concurrent
                      temozolomide. Three days before the patient died, a
                      follow-up FET PET and MRI scan indicated tumor progression.
                      Autopsy was performed 48 hours after death. After formalin
                      fixation, a 7-cm bihemispherical segment of the brain
                      containing the entire tumor mass was cut into 3500
                      consecutive 20μm coronal sections. Representative sections
                      were stained with hematoxylin and eosin stain, cresyl
                      violet, and glial fibrillary acidic protein
                      immunohistochemistry. An experienced neuropathologist
                      identified areas of dense and diffuse neoplastic
                      infiltration, astrogliosis, and necrosis. In vivo FET PET,
                      MRI datasets, and postmortem histology were co-registered
                      and compared by 3 experienced physicians.ResultsIncreased
                      uptake of FET in the area of equivocal contrast enhancement
                      on MRI correlated very well with dense infiltration by vital
                      tumor cells and showed tracer kinetics typical for malignant
                      gliomas. An area of predominantly reactive astrogliosis
                      showed only moderate uptake of FET and tracer kinetics
                      usually observed in benign lesions.ConclusionsThis case
                      report impressively documents the correct imaging of a
                      progressive glioblastoma by FET PET.},
      cin          = {INM-1 / INM-4 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-3-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30077752},
      UT           = {WOS:000447941300079},
      doi          = {10.1016/j.wneu.2018.07.232},
      url          = {https://juser.fz-juelich.de/record/852419},
}