TY  - JOUR
AU  - Sergeeva, Olga A.
AU  - De Luca, Roberto
AU  - Mazur, Karolina
AU  - Chepkova, Aissa N.
AU  - Haas, Helmut L.
AU  - Bauer, Andreas
TI  - N-oleoyldopamine modulates activity of midbrain dopaminergic neurons through multiple mechanisms
JO  - Neuropharmacology
VL  - 119
SN  - 0028-3908
CY  - Amsterdam [u.a.]
PB  - Elsevier Science
M1  - FZJ-2018-05399
SP  - 111 - 122
PY  - 2017
AB  - N-oleoyl-dopamine (OLDA) is an amide of dopamine and oleic acid, synthesized in catecholaminergic neurons. The present study investigates OLDA targets in midbrain dopaminergic (DA) neurons. Substantia Nigra compacta (SNc) DA neurons recorded in brain slices were excited by OLDA in wild type mice. In transient receptor potential vanilloid 1 (TRPV1) knockout (KO) mice, however, SNc DA neurons displayed sustained inhibition of firing. In the presence of the dopamine type 2 receptor (D2R) antagonist sulpiride or the dopamine transporter blocker nomifensine no such inhibition was observed. Under sulpiride OLDA slightly excited SNc DA neurons, an action abolished upon combined application of the cannabinoid1 and 2 receptor antagonists AM251 and AM630. In ventral tegmental area (VTA) DA neurons from TRPV1 KO mice a transient inhibition of firing by OLDA was observed. Thus OLDA modulates the firing of nigrostriatal DA neurons through interactions with TRPV1, cannabinoid receptors and dopamine uptake. These findings suggest further development of OLDA-like tandem molecules for the treatment of movement disorders including Parkinson's disease.
LB  - PUB:(DE-HGF)16
C6  - pmid:28400256
UR  - <Go to ISI:>//WOS:000403513800010
DO  - DOI:10.1016/j.neuropharm.2017.04.011
UR  - https://juser.fz-juelich.de/record/852453
ER  -