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@ARTICLE{Sergeeva:852453,
      author       = {Sergeeva, Olga A. and De Luca, Roberto and Mazur, Karolina
                      and Chepkova, Aissa N. and Haas, Helmut L. and Bauer,
                      Andreas},
      title        = {{N}-oleoyldopamine modulates activity of midbrain
                      dopaminergic neurons through multiple mechanisms},
      journal      = {Neuropharmacology},
      volume       = {119},
      issn         = {0028-3908},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-05399},
      pages        = {111 - 122},
      year         = {2017},
      abstract     = {N-oleoyl-dopamine (OLDA) is an amide of dopamine and oleic
                      acid, synthesized in catecholaminergic neurons. The present
                      study investigates OLDA targets in midbrain dopaminergic
                      (DA) neurons. Substantia Nigra compacta (SNc) DA neurons
                      recorded in brain slices were excited by OLDA in wild type
                      mice. In transient receptor potential vanilloid 1 (TRPV1)
                      knockout (KO) mice, however, SNc DA neurons displayed
                      sustained inhibition of firing. In the presence of the
                      dopamine type 2 receptor (D2R) antagonist sulpiride or the
                      dopamine transporter blocker nomifensine no such inhibition
                      was observed. Under sulpiride OLDA slightly excited SNc DA
                      neurons, an action abolished upon combined application of
                      the cannabinoid1 and 2 receptor antagonists AM251 and AM630.
                      In ventral tegmental area (VTA) DA neurons from TRPV1 KO
                      mice a transient inhibition of firing by OLDA was observed.
                      Thus OLDA modulates the firing of nigrostriatal DA neurons
                      through interactions with TRPV1, cannabinoid receptors and
                      dopamine uptake. These findings suggest further development
                      of OLDA-like tandem molecules for the treatment of movement
                      disorders including Parkinson's disease.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {573 - Neuroimaging (POF3-573) / 571 - Connectivity and
                      Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-573 / G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28400256},
      UT           = {WOS:000403513800010},
      doi          = {10.1016/j.neuropharm.2017.04.011},
      url          = {https://juser.fz-juelich.de/record/852453},
}