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@ARTICLE{Barbul:852738,
      author       = {Barbul, Alexander and Singh, Karandeep and Horev−Azaria,
                      Limor and Dasgupta, Sabyasachi and Auth, Thorsten and
                      Korenstein, Rafi and Gompper, Gerhard},
      title        = {{N}anoparticle-{D}ecorated {E}rythrocytes {R}eveal {T}hat
                      {P}article {S}ize {C}ontrols the {E}xtent of {A}dsorption,
                      {C}ell {S}hape, and {C}ell {D}eformability},
      journal      = {ACS applied nano materials},
      volume       = {1},
      number       = {8},
      issn         = {2574-0970},
      address      = {Washington, DC},
      publisher    = {ACS Publications},
      reportid     = {FZJ-2018-05610},
      pages        = {3785 - 3799},
      year         = {2018},
      abstract     = {Unraveling the interaction of nanoparticles with living
                      cells is fundamental for nanomedicine and nanotoxicology.
                      Erythrocytes are abundant and serve as model cells with
                      well-characterized properties. Quantitative experiments
                      addressing the binding of carboxylated polystyrene
                      nanoparticles to human erythrocytes reveal saturated
                      adsorption with only sparse $(∼2\%)$ coverage of the cell
                      membrane by partial-wrapped nanoparticles. The independence
                      of the adsorbed area on particle size suggests a restricted
                      number of adhesive sites on the membrane. Using a continuum
                      membrane model combined with nanoparticle–membrane
                      adhesion mediated by receptor–ligand bonds, we predict
                      high bond energies and low receptor densities for
                      partial-wrapped particles. With the help of computer
                      simulations, we determine sets of receptor densities,
                      receptor diffusion coefficients, minimal numbers of bound
                      receptors required for multivalent binding, and maximal
                      possible numbers of bound receptors that reproduce the
                      experimental nanoparticle adsorption data. Nanoparticle
                      decoration of erythrocytes leads to shape transformations
                      and reduced cell deformability. We quantitatively
                      characterize and interpret erythrocyte shape and
                      deformability changes. The shape changes also offer insights
                      into the modification of the mechanical properties of other
                      mammalian cell membranes by adhered nanoparticles. A
                      potential application of nanoparticle-loaded erythrocytes is
                      retarded targeted drug delivery with a long lifetime of the
                      particles in the blood circulation.},
      cin          = {ICS-2},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000461400900006},
      doi          = {10.1021/acsanm.8b00357},
      url          = {https://juser.fz-juelich.de/record/852738},
}