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| Hauptseite > Publikationsdatenbank > Phosphocreatine levels in the left thalamus decline during wakefulness and increase after a nap > print |
| Hauptseite > Publikationsdatenbank > Phosphocreatine levels in the left thalamus decline during wakefulness and increase after a nap > print |
| 001 | 852906 | ||
| 005 | 20220930130158.0 | ||
| 024 | 7 | _ | |a 10.1523/JNEUROSCI.0865-18.2018 |2 doi |
| 024 | 7 | _ | |a 0270-6474 |2 ISSN |
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| 037 | _ | _ | |a FZJ-2018-05693 |
| 082 | _ | _ | |a 590 |
| 100 | 1 | _ | |a Gordji-Nejad, Ali |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Phosphocreatine levels in the left thalamus decline during wakefulness and increase after a nap |
| 260 | _ | _ | |a Washington, DC |c 2018 |b Soc. |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a The availability of phosphocreatine (PCr) and the ratio to inorganic phosphate (Pi) in cerebral tissue has been hypothesized a substrate of wakefulness and the exhaustion thereof a substrate of fatigue. We used 31P-magnetic resonance spectroscopy (31P-MRS) to investigate quantitative levels of PCr, the γ-signal of adenosine triphosphate (ATP) and Pi in 30 healthy humans (18 female) in the morning, in the afternoon, and while napping (n = 15) versus wake controls (n = 10).Levels of PCr (2.40 mM at 9 AM) decreased by 7.0 ± 0.8 % (p = 7.1 × 10-6, t = -5.5) in the left thalamus between 9 AM and 5 PM. Inversely, Pi (0.74 mM at 9 AM) increased by 17.1 ± 5 %, (p = .005, t = 3.1) and pH levels dropped by 0.14 ± 0.07 (p = .002; t = 3.6). Following a 20 min nap after 5 PM, local PCr, Pi and pH were restored at morning levels. We did not find respective significant changes in the contralateral thalamus or in other investigated brain regions. Left hemispheric PCr significantly undercut right only at 5 PM in the thalamus but at all conditions in the temporal region.Thus cerebral daytime- and sleep-related molecular changes are accessible in vivo. Prominent changes were identified in the thalamus. This region is highly loaded with a series of energy consuming tasks such as the relay of sensory information to the cortex. Furthermore, our data underline that lateralization of brain function is regionally dynamic and includes PCr. |
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| 700 | 1 | _ | |a Matusch, Andreas |0 P:(DE-Juel1)138474 |b 1 |
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| 700 | 1 | _ | |a Kroll, Tina |0 P:(DE-Juel1)131691 |b 3 |
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| 700 | 1 | _ | |a Elmenhorst, David |0 P:(DE-Juel1)131679 |b 5 |
| 700 | 1 | _ | |a Bauer, Andreas |0 P:(DE-Juel1)140200 |b 6 |
| 773 | _ | _ | |a 10.1523/JNEUROSCI.0865-18.2018 |g p. 0865-18 - |0 PERI:(DE-600)1475274-8 |n 49 |p 10552-10565 |t The journal of neuroscience |v 38 |y 2018 |x 0270-6474 |
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