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@ARTICLE{Basan:852911,
      author       = {Basan, M. and Elgeti, J. and Hannezo, E. and Rappel, W.-J.
                      and Levine, H.},
      title        = {{A}lignment of cellular motility forces with tissue flow as
                      a mechanism for efficient wound healing},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {110},
      number       = {7},
      issn         = {1091-6490},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2018-05698},
      pages        = {2452 - 2459},
      year         = {2013},
      abstract     = {Recent experiments have shown that spreading epithelial
                      sheets exhibit a long-range coordination of motility forces
                      that leads to a buildup of tension in the tissue, which may
                      enhance cell division and the speed of wound healing.
                      Furthermore, the edges of these epithelial sheets commonly
                      show finger-like protrusions whereas the bulk often displays
                      spontaneous swirls of motile cells. To explain these
                      experimental observations, we propose a simple flocking-type
                      mechanism, in which cells tend to align their motility
                      forces with their velocity. Implementing this idea in a
                      mechanical tissue simulation, the proposed model gives rise
                      to efficient spreading and can explain the experimentally
                      observed long-range alignment of motility forces in highly
                      disordered patterns, as well as the buildup of tensile
                      stress throughout the tissue. Our model also qualitatively
                      reproduces the dependence of swirl size and swirl velocity
                      on cell density reported in experiments and exhibits an
                      undulation instability at the edge of the spreading tissue
                      commonly observed in vivo. Finally, we study the dependence
                      of colony spreading speed on important physical and
                      biological parameters and derive simple scaling relations
                      that show that coordination of motility forces leads to an
                      improvement of the wound healing process for realistic
                      tissue parameters.},
      cin          = {ICS-2},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-2-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:23345440},
      UT           = {WOS:000315812800023},
      doi          = {10.1073/pnas.1219937110},
      url          = {https://juser.fz-juelich.de/record/852911},
}