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@ARTICLE{Schmidt:856028,
      author       = {Schmidt, Claudia and Timpert, D. C. and Arend, I. and
                      Vossel, S. and Dovern, A. and Saliger, J. and Karbe, H. and
                      Fink, G. R. and Henik, A. and Weiss-Blankenhorn, Peter},
      title        = {{P}reserved but less efficient control of response
                      interference after unilateral lesions of the striatum.},
      journal      = {Frontiers in human neuroscience},
      volume       = {12},
      issn         = {1662-5161},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-05708},
      pages        = {414},
      year         = {2018},
      abstract     = {Previous research on the neural basis of cognitive control
                      processes has mainly focused on cortical areas, while the
                      role of subcortical structures in cognitive control is less
                      clear. Models of basal ganglia function as well as clinical
                      studies in neurodegenerative diseases suggest that the
                      striatum (putamen and caudate nucleus) modulates the
                      inhibition of interfering responses and thereby contributes
                      to an important aspect of cognitive control, namely response
                      interference control. To further investigate the putative
                      role of the striatum in the control of response
                      interference, 23 patients with stroke-induced lesions of the
                      striatum and 32 age-matched neurologically healthy controls
                      performed a unimanual version of the Simon task. In the
                      Simon task, the correspondence between stimulus location and
                      response location is manipulated so that control over
                      response interference can be inferred from the reaction time
                      costs in incongruent trials. Results showed that stroke
                      patients responded overall slower and more erroneous than
                      controls. The difference in response times (RTs) between
                      incongruent and congruent trials (known as the Simon effect)
                      was smaller in the ipsilesional/-lateral hemifield, but did
                      not differ significantly between groups. However, in
                      contrast to controls, stroke patients exhibited an
                      abnormally stable Simon effect across the reaction time
                      distribution indicating a reduced efficiency of the
                      inhibition process. Thus, in stroke patients unilateral
                      lesions of the striatum did not significantly impair the
                      general ability to control response interference, but led to
                      less efficient selective inhibition of interfering
                      responses.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000447445400001},
      doi          = {10.3389/fnhum.2018.00414},
      url          = {https://juser.fz-juelich.de/record/856028},
}