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000856050 245__ $$aStructural Prediction of the Dimeric Form of the Mammalian Translocator Membrane Protein TSPO: A Key Target for Brain Diagnostics
000856050 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2018
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000856050 520__ $$aPositron emission tomography (PET) radioligands targeting the human translocatormembrane protein (TSPO) are broadly used for the investigations of neuroinflammatory conditionsassociated with neurological disorders. Structural information on the mammalian proteinhomodimers—the suggested functional state of the protein—is limited to a solid-state nuclearmagnetic resonance (NMR) study and to a model based on the previously-deposited solution NMRstructure of the monomeric mouse protein. Computational studies performed here suggest thatthe NMR-solved structure in the presence of detergents is not prone to dimer formation and isfurthermore unstable in its native membrane environment. We, therefore, propose a new modelof the functionally-relevant dimeric form of the mouse protein, based on a prokaryotic homologue.The model, fully consistent with solid-state NMR data, is very different from the previous predictions.Hence, it provides, for the first time, structural insights into this pharmaceutically-important targetwhich are fully consistent with experimental data.
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000856050 7001_ $$0P:(DE-Juel1)172064$$aGuareschi, Riccardo$$b1
000856050 7001_ $$0P:(DE-HGF)0$$aDamre, Mangesh$$b2
000856050 7001_ $$0P:(DE-Juel1)168598$$aCao, Ruyin$$b3
000856050 7001_ $$0P:(DE-HGF)0$$aKless, Achim$$b4
000856050 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b5
000856050 7001_ $$0P:(DE-Juel1)131672$$aBauer, Andreas$$b6$$ufzj
000856050 7001_ $$0P:(DE-Juel1)165199$$aGiorgetti, Alejandro$$b7
000856050 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b8
000856050 7001_ $$0P:(DE-Juel1)145921$$aRossetti, Giulia$$b9$$eCorresponding author
000856050 773__ $$0PERI:(DE-600)2019364-6$$a10.3390/ijms19092588$$gVol. 19, no. 9, p. 2588 -$$n9$$p2588 -$$tInternational journal of molecular sciences$$v19$$x1422-0067$$y2018
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