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@ARTICLE{Schall:856106,
      author       = {Schall, Melissa and Zimmermann, Markus and Iordanishvili,
                      Elene and Gu, Yun and Shah, N. J. and Oros-Peusquens,
                      Ana-Maria},
      title        = {{A} 3{D} two-point method for whole-brain water content and
                      relaxation time mapping: {C}omparison with gold standard
                      methods},
      journal      = {PLOS ONE},
      volume       = {13},
      number       = {8},
      issn         = {1932-6203},
      address      = {San Francisco, California, US},
      publisher    = {PLOS},
      reportid     = {FZJ-2018-05752},
      pages        = {e0201013 -},
      year         = {2018},
      abstract     = {Quantitative imaging of the human brain is of great
                      interest in clinical research as it enables the
                      identification of a range of MR biomarkers useful in
                      diagnosis, treatment and prognosis of a wide spectrum of
                      diseases. Here, a 3D two-point method for water content and
                      relaxation time mapping is presented and compared to
                      established gold standard methods. The method determines
                      free water content, H2O, and the longitudinal relaxation
                      time, T1, quantitatively from a two-point fit to the signal
                      equation including corrections of the transmit and receive
                      fields. In addition, the effective transverse relaxation
                      time, T2*, is obtained from an exponential fit to the
                      multi-echo signal train and its influence on H2O values is
                      corrected. The phantom results obtained with the proposed
                      method show good agreement for H2O and T1 values with known
                      and spectroscopically measured values, respectively. The
                      method is compared in vivo to already established gold
                      standard quantitative methods. For H2O and T2* mapping, the
                      3D two-point results were compared to a measurement
                      conducted with a multiple-echo GRE with long TR and T1 is
                      compared to results from a Look-Locker method, TAPIR. In
                      vivo results show good overall agreement between the
                      methods, but some systematic deviations are present. Besides
                      an expected dependence of T2* on voxel size, T1 values are
                      systematically larger in the 3D approach than those obtained
                      with the gold standard method. This behaviour might be due
                      to imperfect spoiling, influencing each method differently.
                      Results for H2O differ due to differences in the saturation
                      of cerebrospinal fluid and partial volume effects. In
                      addition, ground truth values of in vivo studies are
                      unknown, even when comparing to in vivo gold standard
                      methods. A detailed region-of-interest analysis for H2O and
                      T1 matches well published literature values.},
      cin          = {INM-11 / INM-4 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-11-20170113 / I:(DE-Juel1)INM-4-20090406 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30161125},
      UT           = {WOS:000443388900007},
      doi          = {10.1371/journal.pone.0201013},
      url          = {https://juser.fz-juelich.de/record/856106},
}