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@ARTICLE{Lohmann:856585,
      author       = {Lohmann, P. and Stavrinou, P. and Lipke, K. and Bauer, E.
                      K. and Ceccon, G. and Werner, J. M. and Neumaier, B. and
                      Fink, Gereon Rudolf and Shah, N. J. and Langen, K. J. and
                      Galldiks, N.},
      title        = {{FET} {PET} reveals considerable spatial differences in
                      tumour burden compared to conventional {MRI} in newly
                      diagnosed glioblastoma.},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {46},
      number       = {3},
      issn         = {0340-6997},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2018-05959},
      pages        = {591-602},
      year         = {2019},
      abstract     = {PurposeAreas of contrast enhancement (CE) on MRI are
                      usually the target for resection or radiotherapy target
                      volume definition in glioblastomas. However, the solid
                      tumour mass may extend beyond areas of CE. Amino acid PET
                      can detect parts of the tumour that show no CE. We
                      systematically investigated tumour volumes delineated by
                      amino acid PET and MRI in patients with newly diagnosed,
                      untreated glioblastoma.MethodsPreoperatively, 50 patients
                      with neuropathologically confirmed glioblastoma underwent
                      O-(2-[18F]-fluoroethyl)-l-tyrosine (FET) PET, and
                      fluid-attenuated inversion recovery (FLAIR) and
                      contrast-enhanced MRI. Areas of CE were manually segmented.
                      FET PET tumour volumes were segmented using a
                      tumour-to-brain ratio of ≥1.6. The percentage overlap
                      volumes, and Dice and Jaccard spatial similarity
                      coefficients (DSC, JSC) were calculated. FLAIR images were
                      evaluated visually.ResultsIn 43 patients $(86\%),$ the FET
                      tumour volume was significantly larger than the CE volume
                      (21.5 ± 14.3 mL vs. 9.4 ± 11.3 mL; P < 0.001).
                      Forty patients $(80\%)$ showed both increased uptake of FET
                      and CE. In these 40 patients, the spatial similarity between
                      FET uptake and CE was low (mean DSC 0.39 ± 0.21, mean
                      JSC 0.26 ± 0.16). Ten patients $(20\%)$ showed no CE,
                      and one of these patients showed no FET uptake. In five
                      patients $(10\%),$ increased FET uptake was present outside
                      areas of FLAIR hyperintensity.ConclusionOur results show
                      that the metabolically active tumour volume delineated by
                      FET PET is significantly larger than tumour volume
                      delineated by CE. Furthermore, the results strongly suggest
                      that the information derived from both imaging modalities
                      should be integrated into the management of patients with
                      newly diagnosed glioblastoma.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30327856},
      UT           = {WOS:000457151600007},
      doi          = {10.1007/s00259-018-4188-8},
      url          = {https://juser.fz-juelich.de/record/856585},
}