000856596 001__ 856596 000856596 005__ 20210129235327.0 000856596 0247_ $$2doi$$a10.1016/j.bpsc.2018.07.006 000856596 0247_ $$2ISSN$$a2451-9022 000856596 0247_ $$2ISSN$$a2451-9030 000856596 0247_ $$2Handle$$a2128/21309 000856596 0247_ $$2pmid$$apmid:30197049 000856596 0247_ $$2altmetric$$aaltmetric:46230257 000856596 0247_ $$2WOS$$aWOS:000494360200011 000856596 037__ $$aFZJ-2018-05968 000856596 082__ $$a610 000856596 1001_ $$0P:(DE-HGF)0$$aBarbu, Miruna C.$$b0$$eCorresponding author 000856596 245__ $$aAssociation of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK Biobank 000856596 260__ $$aAmsterdam [u.a.]$$bElsevier Inc.$$c2019 000856596 3367_ $$2DRIVER$$aarticle 000856596 3367_ $$2DataCite$$aOutput Types/Journal article 000856596 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1547822492_26260 000856596 3367_ $$2BibTeX$$aARTICLE 000856596 3367_ $$2ORCID$$aJOURNAL_ARTICLE 000856596 3367_ $$00$$2EndNote$$aJournal Article 000856596 520__ $$aBackgroundMajor depressive disorder is a clinically heterogeneous psychiatric disorder with a polygenic architecture. Genome-wide association studies have identified a number of risk-associated variants across the genome and have reported growing evidence of NETRIN1 pathway involvement. Stratifying disease risk by genetic variation within the NETRIN1 pathway may provide important routes for identification of disease mechanisms by focusing on a specific process, excluding heterogeneous risk-associated variation in other pathways. Here, we sought to investigate whether major depressive disorder polygenic risk scores derived from the NETRIN1 signaling pathway (NETRIN1-PRSs) and the whole genome, excluding NETRIN1 pathway genes (genomic-PRSs), were associated with white matter microstructure.MethodsWe used two diffusion tensor imaging measures, fractional anisotropy (FA) and mean diffusivity (MD), in the most up-to-date UK Biobank neuroimaging data release (FA: n = 6401; MD: n = 6390).ResultsWe found significantly lower FA in the superior longitudinal fasciculus (β = −.035, pcorrected = .029) and significantly higher MD in a global measure of thalamic radiations (β = .029, pcorrected = .021), as well as higher MD in the superior (β = .034, pcorrected = .039) and inferior (β = .029, pcorrected = .043) longitudinal fasciculus and in the anterior (β = .025, pcorrected = .046) and superior (β = .027, pcorrected = .043) thalamic radiation associated with NETRIN1-PRS. Genomic-PRS was also associated with lower FA and higher MD in several tracts.ConclusionsOur findings indicate that variation in the NETRIN1 signaling pathway may confer risk for major depressive disorder through effects on a number of white matter tracts. 000856596 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0 000856596 588__ $$aDataset connected to CrossRef 000856596 7001_ $$aZeng, Yanni$$b1 000856596 7001_ $$aShen, Xueyi$$b2 000856596 7001_ $$aCox, Simon R.$$b3 000856596 7001_ $$aClarke, Toni-Kim$$b4 000856596 7001_ $$aGibson, Jude$$b5 000856596 7001_ $$aAdams, Mark J.$$b6 000856596 7001_ $$00000-0002-8398-0862$$aJohnstone, Mandy$$b7 000856596 7001_ $$aHaley, Chris S.$$b8 000856596 7001_ $$aLawrie, Stephen M.$$b9 000856596 7001_ $$aDeary, Ian J.$$b10 000856596 7001_ $$aMcIntosh, Andrew M.$$b11 000856596 7001_ $$aWhalley, Heather C.$$b12 000856596 7001_ $$aWray, Naomi R.$$b13 000856596 7001_ $$aRipke, Stephan$$b14 000856596 7001_ $$aMattheisen, Manuel$$b15 000856596 7001_ $$aTrzaskowski, Maciej$$b16 000856596 7001_ $$aByrne, Enda M.$$b17 000856596 7001_ $$aAbdellaoui, Abdel$$b18 000856596 7001_ $$aAdams, Mark J.$$b19 000856596 7001_ $$aAgerbo, Esben$$b20 000856596 7001_ $$aAir, Tracy M.$$b21 000856596 7001_ $$aAndlauer, Till F. M.$$b22 000856596 7001_ $$aBacanu, Silviu-Alin$$b23 000856596 7001_ $$aBækvad-Hansen, Marie$$b24 000856596 7001_ $$aBeekman, Aartjan T. F.$$b25 000856596 7001_ $$aBigdeli, Tim B.$$b26 000856596 7001_ $$aBinder, Elisabeth B.$$b27 000856596 7001_ $$aBlackwood, Douglas H. R.$$b28 000856596 7001_ $$aBryois, Julien$$b29 000856596 7001_ $$aButtenschøn, Henriette N.$$b30 000856596 7001_ $$aBybjerg-Grauholm, Jonas$$b31 000856596 7001_ $$aCai, Na$$b32 000856596 7001_ $$aCastelao, Enrique$$b33 000856596 7001_ $$aChristensen, Jane Hvarregaard$$b34 000856596 7001_ $$aClarke, Toni-Kim$$b35 000856596 7001_ $$aColeman, Jonathan R. I.$$b36 000856596 7001_ $$aColodro-Conde, Lucía$$b37 000856596 7001_ $$aCouvy-Duchesne, Baptiste$$b38 000856596 7001_ $$aCraddock, Nick$$b39 000856596 7001_ $$aCrawford, Gregory E.$$b40 000856596 7001_ $$aDavies, Gail$$b41 000856596 7001_ $$aDeary, Ian J.$$b42 000856596 7001_ $$aDegenhardt, Franziska$$b43 000856596 7001_ $$aDerks, Eske M.$$b44 000856596 7001_ $$aDirek, Nese$$b45 000856596 7001_ $$aDolan, Conor V.$$b46 000856596 7001_ $$aDunn, Erin C.$$b47 000856596 7001_ $$aEley, Thalia C.$$b48 000856596 7001_ $$aEscott-Price, Valentina$$b49 000856596 7001_ $$aHassan Kiadeh, Farnush Farhadi$$b50 000856596 7001_ $$aFinucane, Hilary K.$$b51 000856596 7001_ $$aForstner, Andreas J.$$b52 000856596 7001_ $$aFrank, Josef$$b53 000856596 7001_ $$aGaspar, Héléna A.$$b54 000856596 7001_ $$aGill, Michael$$b55 000856596 7001_ $$aGoes, Fernando S.$$b56 000856596 7001_ $$aGordon, Scott D.$$b57 000856596 7001_ $$aGrove, Jakob$$b58 000856596 7001_ $$aHall, Lynsey S.$$b59 000856596 7001_ $$aHansen, Christine Søholm$$b60 000856596 7001_ $$aHansen, Thomas F.$$b61 000856596 7001_ $$aHerms, Stefan$$b62 000856596 7001_ $$aHickie, Ian B.$$b63 000856596 7001_ $$aHoffmann, Per$$b64 000856596 7001_ $$aHomuth, Georg$$b65 000856596 7001_ $$aHorn, Carsten$$b66 000856596 7001_ $$aHottenga, Jouke-Jan$$b67 000856596 7001_ $$aHougaard, David M.$$b68 000856596 7001_ $$aIsing, Marcus$$b69 000856596 7001_ $$aJansen, Rick$$b70 000856596 7001_ $$aJorgenson, Eric$$b71 000856596 7001_ $$aKnowles, James A.$$b72 000856596 7001_ $$aKohane, Isaac S.$$b73 000856596 7001_ $$aKraft, Julia$$b74 000856596 7001_ $$aKretzschmar, Warren W.$$b75 000856596 7001_ $$aKrogh, Jesper$$b76 000856596 7001_ $$aKutalik, Zoltán$$b77 000856596 7001_ $$aLi, Yihan$$b78 000856596 7001_ $$aLind, Penelope A.$$b79 000856596 7001_ $$aMacIntyre, Donald J.$$b80 000856596 7001_ $$aMacKinnon, Dean F.$$b81 000856596 7001_ $$aMaier, Robert M.$$b82 000856596 7001_ $$aMaier, Wolfgang$$b83 000856596 7001_ $$aMarchini, Jonathan$$b84 000856596 7001_ $$aMbarek, Hamdi$$b85 000856596 7001_ $$aMcGrath, Patrick$$b86 000856596 7001_ $$aMcGuffin, Peter$$b87 000856596 7001_ $$aMedland, Sarah E.$$b88 000856596 7001_ $$aMehta, Divya$$b89 000856596 7001_ $$aMiddeldorp, Christel M.$$b90 000856596 7001_ $$aMihailov, Evelin$$b91 000856596 7001_ $$aMilaneschi, Yuri$$b92 000856596 7001_ $$aMilani, Lili$$b93 000856596 7001_ $$aMondimore, Francis M.$$b94 000856596 7001_ $$aMontgomery, Grant W.$$b95 000856596 7001_ $$aMostafavi, Sara$$b96 000856596 7001_ $$aMullins, Niamh$$b97 000856596 7001_ $$aNauck, Matthias$$b98 000856596 7001_ $$aNg, Bernard$$b99 000856596 7001_ $$aNivard, Michel G.$$b100 000856596 7001_ $$aNyholt, Dale R.$$b101 000856596 7001_ $$aO'Reilly, Paul F.$$b102 000856596 7001_ $$aOskarsson, Hogni$$b103 000856596 7001_ $$aOwen, Michael J.$$b104 000856596 7001_ $$aPainter, Jodie N.$$b105 000856596 7001_ $$aPedersen, Carsten Bøcker$$b106 000856596 7001_ $$aPedersen, Marianne Giørtz$$b107 000856596 7001_ $$aPeterson, Roseann E.$$b108 000856596 7001_ $$aPettersson, Erik$$b109 000856596 7001_ $$aPeyrot, Wouter J.$$b110 000856596 7001_ $$aPistis, Giorgio$$b111 000856596 7001_ $$aPosthuma, Danielle$$b112 000856596 7001_ $$aQuiroz, Jorge A.$$b113 000856596 7001_ $$aQvist, Per$$b114 000856596 7001_ $$aRice, John P.$$b115 000856596 7001_ $$aRiley, Brien P.$$b116 000856596 7001_ $$aRivera, Margarita$$b117 000856596 7001_ $$aMirza, Saira Saeed$$b118 000856596 7001_ $$aSchoevers, Robert$$b119 000856596 7001_ $$aSchulte, Eva C.$$b120 000856596 7001_ $$aShen, Ling$$b121 000856596 7001_ $$aShi, Jianxin$$b122 000856596 7001_ $$aShyn, Stanley I.$$b123 000856596 7001_ $$aSigurdsson, Engilbert$$b124 000856596 7001_ $$aSinnamon, Grant C. 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J. C.$$b163 000856596 7001_ $$aDePaulo, J. Raymond$$b164 000856596 7001_ $$aDomenici, Enrico$$b165 000856596 7001_ $$aDomschke, Katharina$$b166 000856596 7001_ $$aEsko, Tõnu$$b167 000856596 7001_ $$aGrabe, Hans J.$$b168 000856596 7001_ $$aHamilton, Steven P.$$b169 000856596 7001_ $$aHayward, Caroline$$b170 000856596 7001_ $$aHeath, Andrew C.$$b171 000856596 7001_ $$aKendler, Kenneth S.$$b172 000856596 7001_ $$aKloiber, Stefan$$b173 000856596 7001_ $$aLewis, Glyn$$b174 000856596 7001_ $$aLi, Qingqin S.$$b175 000856596 7001_ $$aLucae, Susanne$$b176 000856596 7001_ $$aMadden, Pamela A. 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H.$$b190 000856596 7001_ $$aPerlis, Roy H.$$b191 000856596 7001_ $$aPorteous, David J.$$b192 000856596 7001_ $$aPotash, James B.$$b193 000856596 7001_ $$aPreisig, Martin$$b194 000856596 7001_ $$aRietschel, Marcella$$b195 000856596 7001_ $$aSchaefer, Catherine$$b196 000856596 7001_ $$aSchulze, Thomas G.$$b197 000856596 7001_ $$aSmoller, Jordan W.$$b198 000856596 7001_ $$aStefansson, Kari$$b199 000856596 7001_ $$aTiemeier, Henning$$b200 000856596 7001_ $$aUher, Rudolf$$b201 000856596 7001_ $$aVölzke, Henry$$b202 000856596 7001_ $$aWeissman, Myrna M.$$b203 000856596 7001_ $$aWerge, Thomas$$b204 000856596 7001_ $$aLewis, Cathryn M.$$b205 000856596 7001_ $$aLevinson, Douglas F.$$b206 000856596 7001_ $$aBreen, Gerome$$b207 000856596 7001_ $$aBørglum, Anders D.$$b208 000856596 7001_ $$aSullivan, Patrick F.$$b209 000856596 7001_ $$aAgee, Michelle$$b210 000856596 7001_ $$aAlipanahi, Babak$$b211 000856596 7001_ $$aAuton, Adam$$b212 000856596 7001_ $$aBell, Robert K.$$b213 000856596 7001_ $$aBryc, Katarzyna$$b214 000856596 7001_ $$aElson, Sarah L.$$b215 000856596 7001_ $$aFontanillas, Pierre$$b216 000856596 7001_ $$aFurlotte, Nicholas A.$$b217 000856596 7001_ $$aHinds, David A.$$b218 000856596 7001_ $$aHuber, Karen E.$$b219 000856596 7001_ $$aKleinman, Aaron$$b220 000856596 7001_ $$aLitterman, Nadia K.$$b221 000856596 7001_ $$aMcCreight, Jennifer C.$$b222 000856596 7001_ $$aMcIntyre, Matthew H.$$b223 000856596 7001_ $$aMountain, Joanna L.$$b224 000856596 7001_ $$aNoblin, Elizabeth S.$$b225 000856596 7001_ $$aNorthover, Carrie A. M.$$b226 000856596 7001_ $$aPitts, Steven J.$$b227 000856596 7001_ $$aSathirapongsasuti, J. Fah$$b228 000856596 7001_ $$aSazonova, Olga V.$$b229 000856596 7001_ $$aShelton, Janie F.$$b230 000856596 7001_ $$aShringarpure, Suyash$$b231 000856596 7001_ $$aTian, Chao$$b232 000856596 7001_ $$aTung, Joyce Y.$$b233 000856596 7001_ $$aVacic, Vladimir$$b234 000856596 7001_ $$aWilson, Catherine H.$$b235 000856596 773__ $$0PERI:(DE-600)2879089-3$$a10.1016/j.bpsc.2018.07.006$$gp. S2451902218301812$$n1$$p91-100$$tBiological psychiatry Cognitive neuroscience and neuroimaging : cnni cnni$$v4$$x2451-9022$$y2019 000856596 8564_ $$uhttps://juser.fz-juelich.de/record/856596/files/Barbu_etal_Biological_2019.pdf$$yOpenAccess 000856596 8564_ $$uhttps://juser.fz-juelich.de/record/856596/files/Barbu_etal_Biological_2019.pdf?subformat=pdfa$$xpdfa$$yOpenAccess 000856596 909CO $$ooai:juser.fz-juelich.de:856596$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire 000856596 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)140234$$aForschungszentrum Jülich$$b161$$kFZJ 000856596 9131_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0 000856596 9141_ $$y2019 000856596 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS 000856596 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline 000856596 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess 000856596 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0 000856596 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x0 000856596 980__ $$ajournal 000856596 980__ $$aVDB 000856596 980__ $$aUNRESTRICTED 000856596 980__ $$aI:(DE-Juel1)INM-1-20090406 000856596 9801_ $$aFullTexts
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