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@ARTICLE{Barbu:856596,
author = {Barbu, Miruna C. and Zeng, Yanni and Shen, Xueyi and Cox,
Simon R. and Clarke, Toni-Kim and Gibson, Jude and Adams,
Mark J. and Johnstone, Mandy and Haley, Chris S. and Lawrie,
Stephen M. and Deary, Ian J. and McIntosh, Andrew M. and
Whalley, Heather C. and Wray, Naomi R. and Ripke, Stephan
and Mattheisen, Manuel and Trzaskowski, Maciej and Byrne,
Enda M. and Abdellaoui, Abdel and Adams, Mark J. and Agerbo,
Esben and Air, Tracy M. and Andlauer, Till F. M. and Bacanu,
Silviu-Alin and Bækvad-Hansen, Marie and Beekman, Aartjan
T. F. and Bigdeli, Tim B. and Binder, Elisabeth B. and
Blackwood, Douglas H. R. and Bryois, Julien and
Buttenschøn, Henriette N. and Bybjerg-Grauholm, Jonas and
Cai, Na and Castelao, Enrique and Christensen, Jane
Hvarregaard and Clarke, Toni-Kim and Coleman, Jonathan R. I.
and Colodro-Conde, Lucía and Couvy-Duchesne, Baptiste and
Craddock, Nick and Crawford, Gregory E. and Davies, Gail and
Deary, Ian J. and Degenhardt, Franziska and Derks, Eske M.
and Direk, Nese and Dolan, Conor V. and Dunn, Erin C. and
Eley, Thalia C. and Escott-Price, Valentina and Hassan
Kiadeh, Farnush Farhadi and Finucane, Hilary K. and
Forstner, Andreas J. and Frank, Josef and Gaspar, Héléna
A. and Gill, Michael and Goes, Fernando S. and Gordon, Scott
D. and Grove, Jakob and Hall, Lynsey S. and Hansen,
Christine Søholm and Hansen, Thomas F. and Herms, Stefan
and Hickie, Ian B. and Hoffmann, Per and Homuth, Georg and
Horn, Carsten and Hottenga, Jouke-Jan and Hougaard, David M.
and Ising, Marcus and Jansen, Rick and Jorgenson, Eric and
Knowles, James A. and Kohane, Isaac S. and Kraft, Julia and
Kretzschmar, Warren W. and Krogh, Jesper and Kutalik,
Zoltán and Li, Yihan and Lind, Penelope A. and MacIntyre,
Donald J. and MacKinnon, Dean F. and Maier, Robert M. and
Maier, Wolfgang and Marchini, Jonathan and Mbarek, Hamdi and
McGrath, Patrick and McGuffin, Peter and Medland, Sarah E.
and Mehta, Divya and Middeldorp, Christel M. and Mihailov,
Evelin and Milaneschi, Yuri and Milani, Lili and Mondimore,
Francis M. and Montgomery, Grant W. and Mostafavi, Sara and
Mullins, Niamh and Nauck, Matthias and Ng, Bernard and
Nivard, Michel G. and Nyholt, Dale R. and O'Reilly, Paul F.
and Oskarsson, Hogni and Owen, Michael J. and Painter, Jodie
N. and Pedersen, Carsten Bøcker and Pedersen, Marianne
Giørtz and Peterson, Roseann E. and Pettersson, Erik and
Peyrot, Wouter J. and Pistis, Giorgio and Posthuma, Danielle
and Quiroz, Jorge A. and Qvist, Per and Rice, John P. and
Riley, Brien P. and Rivera, Margarita and Mirza, Saira Saeed
and Schoevers, Robert and Schulte, Eva C. and Shen, Ling and
Shi, Jianxin and Shyn, Stanley I. and Sigurdsson, Engilbert
and Sinnamon, Grant C. B. and Smit, Johannes H. and Smith,
Daniel J. and Stefansson, Hreinn and Steinberg, Stacy and
Streit, Fabian and Strohmaier, Jana and Tansey, Katherine E.
and Teismann, Henning and Teumer, Alexander and Thompson,
Wesley and Thomson, Pippa A. and Thorgeirsson, Thorgeir E.
and Traylor, Matthew and Treutlein, Jens and Trubetskoy,
Vassily and Uitterlinden, André G. and Umbricht, Daniel and
Van der Auwera, Sandra and van Hemert, Albert M. and
Viktorin, Alexander and Visscher, Peter M. and Wang, Yunpeng
and Webb, Bradley T. and Weinsheimer, Shantel Marie and
Wellmann, Jürgen and Willemsen, Gonneke and Witt, Stephanie
H. and Wu, Yang and Xi, Hualin S. and Yang, Jian and Zhang,
Futao and Arolt, Volker and Baune, Bernhard T. and Berger,
Klaus and Boomsma, Dorret I. and Cichon, Sven and
Dannlowski, Udo and de Geus, E. J. C. and DePaulo, J.
Raymond and Domenici, Enrico and Domschke, Katharina and
Esko, Tõnu and Grabe, Hans J. and Hamilton, Steven P. and
Hayward, Caroline and Heath, Andrew C. and Kendler, Kenneth
S. and Kloiber, Stefan and Lewis, Glyn and Li, Qingqin S.
and Lucae, Susanne and Madden, Pamela A. F. and Magnusson,
Patrik K. and Martin, Nicholas G. and McIntosh, Andrew M.
and Metspalu, Andres and Mors, Ole and Mortensen, Preben Bo
and Müller-Myhsok, Bertram and Nordentoft, Merete and
Nöthen, Markus M. and O'Donovan, Michael C. and Paciga,
Sara A. and Pedersen, Nancy L. and Penninx, Brenda W. J. H.
and Perlis, Roy H. and Porteous, David J. and Potash, James
B. and Preisig, Martin and Rietschel, Marcella and Schaefer,
Catherine and Schulze, Thomas G. and Smoller, Jordan W. and
Stefansson, Kari and Tiemeier, Henning and Uher, Rudolf and
Völzke, Henry and Weissman, Myrna M. and Werge, Thomas and
Lewis, Cathryn M. and Levinson, Douglas F. and Breen, Gerome
and Børglum, Anders D. and Sullivan, Patrick F. and Agee,
Michelle and Alipanahi, Babak and Auton, Adam and Bell,
Robert K. and Bryc, Katarzyna and Elson, Sarah L. and
Fontanillas, Pierre and Furlotte, Nicholas A. and Hinds,
David A. and Huber, Karen E. and Kleinman, Aaron and
Litterman, Nadia K. and McCreight, Jennifer C. and McIntyre,
Matthew H. and Mountain, Joanna L. and Noblin, Elizabeth S.
and Northover, Carrie A. M. and Pitts, Steven J. and
Sathirapongsasuti, J. Fah and Sazonova, Olga V. and Shelton,
Janie F. and Shringarpure, Suyash and Tian, Chao and Tung,
Joyce Y. and Vacic, Vladimir and Wilson, Catherine H.},
title = {{A}ssociation of {W}hole-{G}enome and {NETRIN}1 {S}ignaling
{P}athway–{D}erived {P}olygenic {R}isk {S}cores for
{M}ajor {D}epressive {D}isorder and {W}hite {M}atter
{M}icrostructure in the {UK} {B}iobank},
journal = {Biological psychiatry Cognitive neuroscience and
neuroimaging : cnni cnni},
volume = {4},
number = {1},
issn = {2451-9022},
address = {Amsterdam [u.a.]},
publisher = {Elsevier Inc.},
reportid = {FZJ-2018-05968},
pages = {91-100},
year = {2019},
abstract = {BackgroundMajor depressive disorder is a clinically
heterogeneous psychiatric disorder with a polygenic
architecture. Genome-wide association studies have
identified a number of risk-associated variants across the
genome and have reported growing evidence of NETRIN1 pathway
involvement. Stratifying disease risk by genetic variation
within the NETRIN1 pathway may provide important routes for
identification of disease mechanisms by focusing on a
specific process, excluding heterogeneous risk-associated
variation in other pathways. Here, we sought to investigate
whether major depressive disorder polygenic risk scores
derived from the NETRIN1 signaling pathway (NETRIN1-PRSs)
and the whole genome, excluding NETRIN1 pathway genes
(genomic-PRSs), were associated with white matter
microstructure.MethodsWe used two diffusion tensor imaging
measures, fractional anisotropy (FA) and mean diffusivity
(MD), in the most up-to-date UK Biobank neuroimaging data
release (FA: n = 6401; MD: n = 6390).ResultsWe found
significantly lower FA in the superior longitudinal
fasciculus (β = −.035, pcorrected = .029) and
significantly higher MD in a global measure of thalamic
radiations (β = .029, pcorrected = .021), as well as higher
MD in the superior (β = .034, pcorrected = .039) and
inferior (β = .029, pcorrected = .043) longitudinal
fasciculus and in the anterior (β = .025, pcorrected =
.046) and superior (β = .027, pcorrected = .043) thalamic
radiation associated with NETRIN1-PRS. Genomic-PRS was also
associated with lower FA and higher MD in several
tracts.ConclusionsOur findings indicate that variation in
the NETRIN1 signaling pathway may confer risk for major
depressive disorder through effects on a number of white
matter tracts.},
cin = {INM-1},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30197049},
UT = {WOS:000494360200011},
doi = {10.1016/j.bpsc.2018.07.006},
url = {https://juser.fz-juelich.de/record/856596},
}
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