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@ARTICLE{Schmitz:856602,
      author       = {Schmitz, Daniel and Münzing, Sascha and Schober, Martin
                      and Schubert, Nicole and Minnerop, Martina and Lippert,
                      Thomas and Amunts, Katrin and Axer, Markus},
      title        = {{D}erivation of {F}iber {O}rientations {F}rom {O}blique
                      {V}iews {T}hrough {H}uman {B}rain {S}ections in
                      3{D}-{P}olarized {L}ight {I}maging},
      journal      = {Frontiers in neuroanatomy},
      volume       = {12},
      issn         = {1662-5129},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-05974},
      pages        = {75},
      year         = {2018},
      abstract     = {3D-Polarized Light Imaging (3D-PLI) enables high-resolution
                      three-dimensional mapping of the nerve fiber architecture in
                      unstained histological brain sections based on the intrinsic
                      birefringence of myelinated nerve fibers. The interpretation
                      of the measured birefringent signals comes with conjointly
                      measured information about the local fiber birefringence
                      strength and the fiber orientation. In this study, we
                      present a novel approach to disentangle both parameters from
                      each other based on a weighted least squares routine (ROFL)
                      applied to oblique polarimetric 3D-PLI measurements. This
                      approach was compared to a previously described analytical
                      method on simulated and experimental data obtained from a
                      post mortem human brain. Analysis of the simulations
                      revealed in case of ROFL a distinctly increased level of
                      confidence to determine steep and flat fiber orientations
                      with respect to the brain sectioning plane. Based on
                      analysis of histological sections of a human brain dataset,
                      it was demonstrated that ROFL provides a coherent
                      characterization of cortical, subcortical, and white matter
                      regions in terms of fiber orientation and birefringence
                      strength, within and across sections. Oblique measurements
                      combined with ROFL analysis opens up new ways to determine
                      physical brain tissue properties by means of 3D-PLI
                      microscopy},
      cin          = {INM-1 / JSC / JARA-HPC},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)JSC-20090406 /
                      $I:(DE-82)080012_20140620$},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / 511 -
                      Computational Science and Mathematical Methods (POF3-511) /
                      HBP SGA2 - Human Brain Project Specific Grant Agreement 2
                      (785907) / HBP SGA1 - Human Brain Project Specific Grant
                      Agreement 1 (720270) / 3D Reconstruction of Nerve Fibers in
                      the Human, the Monkey, the Rodent, and the Pigeon Brain
                      $(jinm11_20181101)$},
      pid          = {G:(DE-HGF)POF3-574 / G:(DE-HGF)POF3-511 /
                      G:(EU-Grant)785907 / G:(EU-Grant)720270 /
                      $G:(DE-Juel1)jinm11_20181101$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30323745},
      UT           = {WOS:000445758400001},
      doi          = {10.3389/fnana.2018.00075},
      url          = {https://juser.fz-juelich.de/record/856602},
}