000856731 001__ 856731
000856731 005__ 20210129235354.0
000856731 0247_ $$2doi$$a10.1016/j.jcis.2018.08.066
000856731 0247_ $$2ISSN$$a0021-9797
000856731 0247_ $$2ISSN$$a1095-7103
000856731 0247_ $$2pmid$$apmid:30216837
000856731 0247_ $$2WOS$$aWOS:000449235600012
000856731 037__ $$aFZJ-2018-06082
000856731 082__ $$a540
000856731 1001_ $$0P:(DE-HGF)0$$aKanwar, Rohini$$b0
000856731 245__ $$aEffect of lipid chain length on nanostructured lipid carriers: Comprehensive structural evaluation by scattering techniques
000856731 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2019
000856731 3367_ $$2DRIVER$$aarticle
000856731 3367_ $$2DataCite$$aOutput Types/Journal article
000856731 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1542898906_6135
000856731 3367_ $$2BibTeX$$aARTICLE
000856731 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000856731 3367_ $$00$$2EndNote$$aJournal Article
000856731 520__ $$aThe objective of the present investigation was to evaluate nano-dispersed systems of differently chained lipids (solid phases) using various scattering techniques. Nanostructured lipid carriers (NLCs) were fabricated by employing the microemulsification methodology in which dialkyldimethyl ammonium bromide (DxDAB) of different alkyl chain length (x=12, 14, 16, 18) and oleic acid were used as the solid lipid and liquid lipid, respectively. For the first time, the effect of DxDAB as a function of the chain length of the double alkyl chain on the structural characteristics of NLCs was investigated. Dynamic light scattering (DLS) and static light scattering (SLS) results showed that a small but systematic size increase occurs with increase in the chain length ‘x’ of the DxDAB from 12 to 16, yet D18DAB based NLCs exhibited the smallest size irrespective of its higher hydrophobicity. Small angle neutron scattering (SANS) analysis revealed the structural make up of NLCs having spherical nanoparticles and triaxial ellipsoidal core-shell micelles in the system. In-vitro cytotoxicity evaluation indicated that toxicity is simply concentration-dependent phenomena and NLCs with less than 5 mg/mL are preferred for better in-vivo tolerance.
000856731 536__ $$0G:(DE-HGF)POF3-6G4$$a6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)$$cPOF3-623$$fPOF III$$x0
000856731 536__ $$0G:(DE-HGF)POF3-6G15$$a6G15 - FRM II / MLZ (POF3-6G15)$$cPOF3-6G15$$fPOF III$$x1
000856731 588__ $$aDataset connected to CrossRef
000856731 65027 $$0V:(DE-MLZ)SciArea-110$$2V:(DE-HGF)$$aChemistry$$x0
000856731 65027 $$0V:(DE-MLZ)SciArea-190$$2V:(DE-HGF)$$aMedicine$$x1
000856731 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and  Proteins$$x0
000856731 693__ $$0EXP:(DE-MLZ)KWS1-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)KWS1-20140101$$6EXP:(DE-MLZ)NL3b-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz $$eKWS-1: Small angle scattering diffractometer$$fNL3b$$x0
000856731 7001_ $$00000-0002-7262-7115$$aGradzielski, Michael$$b1$$eCorresponding author
000856731 7001_ $$0P:(DE-HGF)0$$aPrevost, Sylvain$$b2
000856731 7001_ $$0P:(DE-HGF)0$$aKaur, Gurpreet$$b3
000856731 7001_ $$0P:(DE-HGF)0$$aClemens, Daniel$$b4
000856731 7001_ $$0P:(DE-Juel1)130507$$aAppavou, Marie-Sousai$$b5$$ufzj
000856731 7001_ $$0P:(DE-HGF)0$$aMehta, Surinder Kumar$$b6$$eCorresponding author
000856731 773__ $$0PERI:(DE-600)1469021-4$$a10.1016/j.jcis.2018.08.066$$gVol. 534, p. 95 - 104$$p95 - 104$$tJournal of colloid and interface science$$v534$$x0021-9797$$y2019
000856731 8564_ $$uhttps://juser.fz-juelich.de/record/856731/files/1-s2.0-S0021979718309822-main.pdf$$yRestricted
000856731 8564_ $$uhttps://juser.fz-juelich.de/record/856731/files/1-s2.0-S0021979718309822-main.pdf?subformat=pdfa$$xpdfa$$yRestricted
000856731 909CO $$ooai:juser.fz-juelich.de:856731$$pVDB$$pVDB:MLZ
000856731 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)130507$$aForschungszentrum Jülich$$b5$$kFZJ
000856731 9131_ $$0G:(DE-HGF)POF3-623$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G4$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vFacility topic: Neutrons for Research on Condensed Matter$$x0
000856731 9131_ $$0G:(DE-HGF)POF3-6G15$$1G:(DE-HGF)POF3-6G0$$2G:(DE-HGF)POF3-600$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G15$$aDE-HGF$$bForschungsbereich Materie$$lGroßgeräte: Materie$$vFRM II / MLZ$$x1
000856731 9141_ $$y2019
000856731 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000856731 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000856731 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bJ COLLOID INTERF SCI : 2017
000856731 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000856731 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000856731 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000856731 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000856731 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000856731 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000856731 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000856731 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000856731 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bJ COLLOID INTERF SCI : 2017
000856731 920__ $$lyes
000856731 9201_ $$0I:(DE-Juel1)JCNS-FRM-II-20110218$$kJCNS-FRM-II$$lJCNS-FRM-II$$x0
000856731 9201_ $$0I:(DE-Juel1)JCNS-1-20110106$$kNeutronenstreuung ; JCNS-1$$lNeutronenstreuung $$x1
000856731 980__ $$ajournal
000856731 980__ $$aVDB
000856731 980__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218
000856731 980__ $$aI:(DE-Juel1)JCNS-1-20110106
000856731 980__ $$aUNRESTRICTED