TY  - JOUR
AU  - Kanwar, Rohini
AU  - Gradzielski, Michael
AU  - Prevost, Sylvain
AU  - Kaur, Gurpreet
AU  - Clemens, Daniel
AU  - Appavou, Marie-Sousai
AU  - Mehta, Surinder Kumar
TI  - Effect of lipid chain length on nanostructured lipid carriers: Comprehensive structural evaluation by scattering techniques
JO  - Journal of colloid and interface science
VL  - 534
SN  - 0021-9797
CY  - Amsterdam [u.a.]
PB  - Elsevier
M1  - FZJ-2018-06082
SP  - 95 - 104
PY  - 2019
AB  - The objective of the present investigation was to evaluate nano-dispersed systems of differently chained lipids (solid phases) using various scattering techniques. Nanostructured lipid carriers (NLCs) were fabricated by employing the microemulsification methodology in which dialkyldimethyl ammonium bromide (DxDAB) of different alkyl chain length (x=12, 14, 16, 18) and oleic acid were used as the solid lipid and liquid lipid, respectively. For the first time, the effect of DxDAB as a function of the chain length of the double alkyl chain on the structural characteristics of NLCs was investigated. Dynamic light scattering (DLS) and static light scattering (SLS) results showed that a small but systematic size increase occurs with increase in the chain length ‘x’ of the DxDAB from 12 to 16, yet D18DAB based NLCs exhibited the smallest size irrespective of its higher hydrophobicity. Small angle neutron scattering (SANS) analysis revealed the structural make up of NLCs having spherical nanoparticles and triaxial ellipsoidal core-shell micelles in the system. In-vitro cytotoxicity evaluation indicated that toxicity is simply concentration-dependent phenomena and NLCs with less than 5 mg/mL are preferred for better in-vivo tolerance.
LB  - PUB:(DE-HGF)16
C6  - pmid:30216837
UR  - <Go to ISI:>//WOS:000449235600012
DO  - DOI:10.1016/j.jcis.2018.08.066
UR  - https://juser.fz-juelich.de/record/856731
ER  -