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@ARTICLE{Kanwar:856731,
      author       = {Kanwar, Rohini and Gradzielski, Michael and Prevost,
                      Sylvain and Kaur, Gurpreet and Clemens, Daniel and Appavou,
                      Marie-Sousai and Mehta, Surinder Kumar},
      title        = {{E}ffect of lipid chain length on nanostructured lipid
                      carriers: {C}omprehensive structural evaluation by
                      scattering techniques},
      journal      = {Journal of colloid and interface science},
      volume       = {534},
      issn         = {0021-9797},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2018-06082},
      pages        = {95 - 104},
      year         = {2019},
      abstract     = {The objective of the present investigation was to evaluate
                      nano-dispersed systems of differently chained lipids (solid
                      phases) using various scattering techniques. Nanostructured
                      lipid carriers (NLCs) were fabricated by employing the
                      microemulsification methodology in which dialkyldimethyl
                      ammonium bromide (DxDAB) of different alkyl chain length
                      (x=12, 14, 16, 18) and oleic acid were used as the solid
                      lipid and liquid lipid, respectively. For the first time,
                      the effect of DxDAB as a function of the chain length of the
                      double alkyl chain on the structural characteristics of NLCs
                      was investigated. Dynamic light scattering (DLS) and static
                      light scattering (SLS) results showed that a small but
                      systematic size increase occurs with increase in the chain
                      length ‘x’ of the DxDAB from 12 to 16, yet D18DAB based
                      NLCs exhibited the smallest size irrespective of its higher
                      hydrophobicity. Small angle neutron scattering (SANS)
                      analysis revealed the structural make up of NLCs having
                      spherical nanoparticles and triaxial ellipsoidal core-shell
                      micelles in the system. In-vitro cytotoxicity evaluation
                      indicated that toxicity is simply concentration-dependent
                      phenomena and NLCs with less than 5 mg/mL are preferred for
                      better in-vivo tolerance.},
      cin          = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
                      / 6G15 - FRM II / MLZ (POF3-6G15)},
      pid          = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
      experiment   = {EXP:(DE-MLZ)KWS1-20140101},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30216837},
      UT           = {WOS:000449235600012},
      doi          = {10.1016/j.jcis.2018.08.066},
      url          = {https://juser.fz-juelich.de/record/856731},
}