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@ARTICLE{Dang:856884,
      author       = {Dang, Ka My and Rinklin, Philipp and Afanasenkau, Dzmitry
                      and Westmeyer, Gil and Schürholz, Tobias and Wiegand,
                      Simone and Wolfrum, Bernhard},
      title        = {{C}hip-{B}ased {H}eat {S}timulation for {M}odulating
                      {S}ignal {P}ropagation in {HL}-1 {C}ell {N}etworks},
      journal      = {Advanced biosystems},
      volume       = {2},
      issn         = {2366-7478},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2018-06216},
      pages        = {1800138 -},
      year         = {2018},
      abstract     = {Signal propagation in cardiac cell networks can be
                      modulated by heat stimulation. Here, we investigate the
                      response of a connected HL-1 cardiomyocyte cell network to
                      the application of confined heat stimuli using Ca2+ imaging.
                      Localized temperature gradients are generated by resistive
                      heating via microwire arrays on a chip surface, which serves
                      as a substrate for growing a confluent cell network. We
                      demonstrate that upon heat stimulation, the velocity of the
                      propagating Ca2+ wave in the network is locally increased,
                      leading to a deformation of the wavefront. Furthermore, we
                      show evidence of a change in the signal propagation
                      direction caused by a relocation of the pacemaker cell. This
                      effect might be used in future applications, where heat is
                      employed as an alternative modality for cell stimulation
                      protocols.},
      cin          = {ICS-3},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-3-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000452532700006},
      doi          = {10.1002/adbi.201800138},
      url          = {https://juser.fz-juelich.de/record/856884},
}