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005     20240619083548.0
024 7 _ |a 10.1002/adbi.201800138
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082 _ _ |a 570
100 1 _ |a Dang, Ka My
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245 _ _ |a Chip-Based Heat Stimulation for Modulating Signal Propagation in HL-1 Cell Networks
260 _ _ |a Weinheim
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520 _ _ |a Signal propagation in cardiac cell networks can be modulated by heat stimulation. Here, we investigate the response of a connected HL-1 cardiomyocyte cell network to the application of confined heat stimuli using Ca2+ imaging. Localized temperature gradients are generated by resistive heating via microwire arrays on a chip surface, which serves as a substrate for growing a confluent cell network. We demonstrate that upon heat stimulation, the velocity of the propagating Ca2+ wave in the network is locally increased, leading to a deformation of the wavefront. Furthermore, we show evidence of a change in the signal propagation direction caused by a relocation of the pacemaker cell. This effect might be used in future applications, where heat is employed as an alternative modality for cell stimulation protocols.
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700 1 _ |a Rinklin, Philipp
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700 1 _ |a Afanasenkau, Dzmitry
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700 1 _ |a Westmeyer, Gil
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700 1 _ |a Schürholz, Tobias
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700 1 _ |a Wiegand, Simone
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700 1 _ |a Wolfrum, Bernhard
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773 _ _ |a 10.1002/adbi.201800138
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856 4 _ |u https://juser.fz-juelich.de/record/856884/files/Dang_et_al-2018-Advanced_Biosystems.pdf
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