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000857021 1001_ $$0P:(DE-HGF)0$$aRisi, Cristina$$b0
000857021 245__ $$aN-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament
000857021 260__ $$aCambridge, Mass.$$bCell Press$$c2018
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000857021 520__ $$aMuscle contraction relies on interaction betweenmyosin-based thick filaments and actin-based thinfilaments. Myosin binding protein C (MyBP-C) is akey regulator of actomyosin interactions. Recentstudies established that the N0-terminal domains(NTDs) of MyBP-C can either activate or inhibit thinfilaments, but the mechanism of their collectiveaction is poorly understood. Cardiac MyBP-C(cMyBP-C) harbors an extra NTD, which is absentin skeletal isoforms of MyBP-C, and its role in regulationof cardiac contraction is unknown. Here weshow that the first two domains of human cMyPB-C(i.e., C0 and C1) cooperate to activate the thin filament.We demonstrate that C1 interacts with tropomyosinvia a positively charged loop and that thisinteraction, stabilized by the C0 domain, is requiredfor thin filament activation by cMyBP-C. Our datareveal a mechanism by which cMyBP-C can modulatecardiac contraction and demonstrate a function of the C0 domain.
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000857021 7001_ $$0P:(DE-HGF)0$$aBelknap, Betty$$b1
000857021 7001_ $$0P:(DE-HGF)0$$aForgacs-Lonart, Eva$$b2
000857021 7001_ $$0P:(DE-HGF)0$$aHarris, Samantha P.$$b3
000857021 7001_ $$0P:(DE-Juel1)132018$$aSchröder, Gunnar$$b4
000857021 7001_ $$0P:(DE-HGF)0$$aWhite, Howard D.$$b5
000857021 7001_ $$0P:(DE-HGF)0$$aGalkin, Vitold E.$$b6$$eCorresponding author
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