% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Risi:857021,
      author       = {Risi, Cristina and Belknap, Betty and Forgacs-Lonart, Eva
                      and Harris, Samantha P. and Schröder, Gunnar and White,
                      Howard D. and Galkin, Vitold E.},
      title        = {{N}-{T}erminal {D}omains of {C}ardiac {M}yosin {B}inding
                      {P}rotein {C} {C}ooperatively {A}ctivate the {T}hin
                      {F}ilament},
      journal      = {Structure},
      volume       = {26},
      number       = {12},
      issn         = {0969-2126},
      address      = {Cambridge, Mass.},
      publisher    = {Cell Press},
      reportid     = {FZJ-2018-06302},
      pages        = {1604-1611.e4},
      year         = {2018},
      abstract     = {Muscle contraction relies on interaction
                      betweenmyosin-based thick filaments and actin-based
                      thinfilaments. Myosin binding protein C (MyBP-C) is akey
                      regulator of actomyosin interactions. Recentstudies
                      established that the N0-terminal domains(NTDs) of MyBP-C can
                      either activate or inhibit thinfilaments, but the mechanism
                      of their collectiveaction is poorly understood. Cardiac
                      MyBP-C(cMyBP-C) harbors an extra NTD, which is absentin
                      skeletal isoforms of MyBP-C, and its role in regulationof
                      cardiac contraction is unknown. Here weshow that the first
                      two domains of human cMyPB-C(i.e., C0 and C1) cooperate to
                      activate the thin filament.We demonstrate that C1 interacts
                      with tropomyosinvia a positively charged loop and that
                      thisinteraction, stabilized by the C0 domain, is requiredfor
                      thin filament activation by cMyBP-C. Our datareveal a
                      mechanism by which cMyBP-C can modulatecardiac contraction
                      and demonstrate a function of the C0 domain.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30270174},
      UT           = {WOS:000454803300007},
      doi          = {10.1016/j.str.2018.08.007},
      url          = {https://juser.fz-juelich.de/record/857021},
}