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| Hauptseite > Publikationsdatenbank > N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament > print |
| Hauptseite > Publikationsdatenbank > N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament > print |
| 001 | 857021 | ||
| 005 | 20210129235441.0 | ||
| 024 | 7 | _ | |a 10.1016/j.str.2018.08.007 |2 doi |
| 024 | 7 | _ | |a 0969-2126 |2 ISSN |
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| 037 | _ | _ | |a FZJ-2018-06302 |
| 082 | _ | _ | |a 540 |
| 100 | 1 | _ | |a Risi, Cristina |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a N-Terminal Domains of Cardiac Myosin Binding Protein C Cooperatively Activate the Thin Filament |
| 260 | _ | _ | |a Cambridge, Mass. |c 2018 |b Cell Press |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1547822906_26260 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Muscle contraction relies on interaction betweenmyosin-based thick filaments and actin-based thinfilaments. Myosin binding protein C (MyBP-C) is akey regulator of actomyosin interactions. Recentstudies established that the N0-terminal domains(NTDs) of MyBP-C can either activate or inhibit thinfilaments, but the mechanism of their collectiveaction is poorly understood. Cardiac MyBP-C(cMyBP-C) harbors an extra NTD, which is absentin skeletal isoforms of MyBP-C, and its role in regulationof cardiac contraction is unknown. Here weshow that the first two domains of human cMyPB-C(i.e., C0 and C1) cooperate to activate the thin filament.We demonstrate that C1 interacts with tropomyosinvia a positively charged loop and that thisinteraction, stabilized by the C0 domain, is requiredfor thin filament activation by cMyBP-C. Our datareveal a mechanism by which cMyBP-C can modulatecardiac contraction and demonstrate a function of the C0 domain. |
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| 700 | 1 | _ | |a Belknap, Betty |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Forgacs-Lonart, Eva |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Harris, Samantha P. |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Schröder, Gunnar |0 P:(DE-Juel1)132018 |b 4 |
| 700 | 1 | _ | |a White, Howard D. |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Galkin, Vitold E. |0 P:(DE-HGF)0 |b 6 |e Corresponding author |
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