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@ARTICLE{Muecke:857094,
      author       = {Muecke, Hannah and Richter, Nils and von Reutern, Boris and
                      Kukolja, Juraj and Fink, Gereon R. and Onur, Oezguer A.},
      title        = {{D}ifferential {E}ffect of {R}etroactive {I}nterference on
                      {O}bject and {S}patial {M}emory in the {C}ourse of {H}ealthy
                      {A}ging and {N}eurodegeneration},
      journal      = {Frontiers in aging neuroscience},
      volume       = {10},
      issn         = {1663-4365},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-06348},
      pages        = {333},
      year         = {2018},
      abstract     = {Objective: In subjects with mild cognitive impairment
                      (MCI), interference during memory consolidation may further
                      degrade subsequent recall of newly learned information. We
                      investigated whether spatial and object memory are
                      differentially susceptible to interference.Method:
                      Thirty-nine healthy young subjects, 39 healthy older
                      subjects, and 12 subjects suffering from MCI encoded objects
                      and their spatial position on a 4-by-5 grid. Encoding was
                      followed by either: (i) a pause; (ii) an interference task
                      immediately following encoding; or (iii) an interference
                      task following encoding after a 6-min delay. Type of
                      interference (no, early, delayed) was applied in different
                      sessions and order was counterbalanced. Twelve minutes after
                      encoding, subjects saw objects previously presented or new
                      ones. Subjects indicated whether they recognized the object,
                      and if so, the objects’ position during encoding.Results:
                      Interference during consolidation provoked a negative effect
                      on spatial memory in young more than older controls. In MCI,
                      object but not spatial memory was affected by interference.
                      Furthermore, a shift from fine- to coarse-grained spatial
                      representation was observed in MCI. No differential effect
                      of early vs. late interference (EI vs. LI) in either of the
                      groups was detected.Conclusions: Data show that
                      consolidation in healthy aging and MCI differs from
                      consolidation in young controls. Data suggest differential
                      processes underlying object and spatial memory and that
                      these are differentially affected by aging and MCI.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30405401},
      UT           = {WOS:000448037000001},
      doi          = {10.3389/fnagi.2018.00333},
      url          = {https://juser.fz-juelich.de/record/857094},
}