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@ARTICLE{Nackaerts:857147,
      author       = {Nackaerts, Evelien and Michely, Jochen and Heremans, Elke
                      and Swinnen, Stephan and Smits-Engelsman, Bouwien and
                      Vandenberghe, Wim and Grefkes, Christian and Nieuwboer,
                      Alice},
      title        = {{B}eing on {T}arget: {V}isual {I}nformation during
                      {W}riting {A}ffects {E}ffective {C}onnectivity in
                      {P}arkinson’s {D}isease},
      journal      = {Neuroscience},
      volume       = {371},
      issn         = {0306-4522},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2018-06391},
      pages        = {484 - 494},
      year         = {2018},
      abstract     = {A common motor symptom of Parkinson’s disease (PD) is
                      micrographia, characterized by a decrease in writing
                      amplitude. Despite the relevance of this impairment for
                      activities of daily living, the underlying neural network
                      abnormalities and the impact of cueing strategies on brain
                      connectivity are unknown. Therefore, we investigated the
                      effects of visual cues on visuomotor network interactions
                      during handwriting in PD and healthy controls (HCs).
                      Twenty-eight patients with early disease, ON dopaminergic
                      medication, and 14 age-matched controls performed a
                      pre-writing task with and without visual cues in the
                      scanner. Patients displayed weaker right visuo-parietal
                      coupling than controls, suggesting impaired visuomotor
                      integration during writing. Surprisingly, cueing did not
                      have the expected positive effects on writing performance.
                      Patients and controls, however, did activate similar
                      networks during cued and uncued writing. During cued
                      writing, the stronger influence of both visual and motor
                      areas on the left superior parietal lobe suggested that
                      visual cueing induced greater visual steering. In the
                      absence of cues, there was enhanced coupling between
                      parietal and supplementary motor areas (SMA) in line with
                      previous findings in HCs during uncued motor tasks. In
                      conclusion, the present study showed that patients with PD,
                      despite their compromised brain function, were able to shift
                      neural networks similar to controls. However, it seemed that
                      visual cues provided a greater accuracy constraint on
                      handwriting rather than offering unequivocal beneficial
                      effects. Altogether, the results suggest that the
                      effectiveness of using compensatory neural networks through
                      applying external stimuli is task dependent and may
                      compromise motor control during writing.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29294336},
      UT           = {WOS:000425876200039},
      doi          = {10.1016/j.neuroscience.2017.12.027},
      url          = {https://juser.fz-juelich.de/record/857147},
}