TY  - JOUR
AU  - Blundell, Inga
AU  - Brette, Romain
AU  - Cleland, Thomas A.
AU  - Close, Thomas G.
AU  - Coca, Daniel
AU  - Davison, Andrew P.
AU  - Diaz, Sandra
AU  - Fernandez Musoles, Carlos
AU  - Gleeson, Padraig
AU  - Goodman, Dan F. M.
AU  - Hines, Michael
AU  - Hopkins, Michael W.
AU  - Kumbhar, Pramod
AU  - Lester, David R.
AU  - Marin, Bóris
AU  - Morrison, Abigail
AU  - Müller, Eric
AU  - Nowotny, Thomas
AU  - Peyser, Alexander
AU  - Plotnikov, Dimitri
AU  - Richmond, Paul
AU  - Rowley, Andrew
AU  - Rumpe, Bernhard
AU  - Stimberg, Marcel
AU  - Stokes, Alan B.
AU  - Tomkins, Adam
AU  - Trensch, Guido
AU  - Woodman, Marmaduke
AU  - Eppler, Jochen Martin
TI  - Code Generation in Computational Neuroscience: A Review of Tools and Techniques
JO  - Frontiers in neuroinformatics
VL  - 12
SN  - 1662-5196
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - FZJ-2018-06402
SP  - 68
PY  - 2018
AB  - Advances in experimental techniques and computational power allowing researchers to gather anatomical and electrophysiological data at unprecedented levels of detail have fostered the development of increasingly complex models in computational neuroscience. Large-scale, biophysically detailed cell models pose a particular set of computational challenges, and this has led to the development of a number of domain-specific simulators. At the other level of detail, the ever growing variety of point neuron models increases the implementation barrier even for those based on the relatively simple integrate-and-fire neuron model. Independently of the model complexity, all modeling methods crucially depend on an efficient and accurate transformation of mathematical model descriptions into efficiently executable code. Neuroscientists usually publish model descriptions in terms of the mathematical equations underlying them. However, actually simulating them requires they be translated into code. This can cause problems because errors may be introduced if this process is carried out by hand, and code written by neuroscientists may not be very computationally efficient. Furthermore, the translated code might be generated for different hardware platforms, operating system variants or even written in different languages and thus cannot easily be combined or even compared. Two main approaches to addressing this issues have been followed. The first is to limit users to a fixed set of optimized models, which limits flexibility. The second is to allow model definitions in a high level interpreted language, although this may limit performance. Recently, a third approach has become increasingly popular: using code generation to automatically translate high level descriptions into efficient low level code to combine the best of previous approaches. This approach also greatly enriches efforts to standardize simulator-independent model description languages. In the past few years, a number of code generation pipelines have been developed in the computational neuroscience community, which differ considerably in aim, scope and functionality. This article provides an overview of existing pipelines currently used within the community and contrasts their capabilities and the technologies and concepts behind them.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000449250100001
C6  - pmid:30455637
DO  - DOI:10.3389/fninf.2018.00068
UR  - https://juser.fz-juelich.de/record/857165
ER  -