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@ARTICLE{RivasAiello:857577,
      author       = {Rivas Aiello, María Belén and Castrogiovanni, Daniel and
                      Parisi, Julieta and Azcárate, Julio C. and García
                      Einschlag, Fernando S. and Gensch, Thomas and Bosio,
                      Gabriela N. and Mártire, Daniel O.},
      title        = {{P}hotodynamic {T}herapy in {H}e{L}a {C}ells {I}ncubated
                      with {R}iboflavin and {P}ectin-coated {S}ilver
                      {N}anoparticles},
      journal      = {Photochemistry and photobiology},
      volume       = {94},
      number       = {6},
      issn         = {0031-8655},
      address      = {Washington, DC},
      publisher    = {BioOne},
      reportid     = {FZJ-2018-06562},
      pages        = {1159 - 1166},
      year         = {2018},
      abstract     = {Riboflavin (Rf) is an endogenous photosensitizer, which can
                      participate in Type I and Type II processes. We have
                      recently shown that the yield of the triplet excited states
                      of Rf is enhanced in the presence of pectin‐coated silver
                      nanoparticles (Pec@AgNP) due to formation of a complex
                      between Rf and Pec@AgNP (Rf‐Pec@AgNP). Consequently, under
                      aerobic conditions, the amounts of singlet molecular oxygen
                      and superoxide radical anion generated are also larger in
                      the presence of the nanoparticles. This result made us
                      suspect that the nanoparticles could have a beneficial
                      effect in Rf‐based PDT. To prove this hypothesis, we here
                      compared the photodamage in HeLa cells incubated with Rf in
                      the presence and in the absence of Pec@AgNP applying several
                      optical assays. We used fluorescence imaging of irradiated
                      HeLa cells incubated with Annexin V and propidium iodide to
                      evaluate the occurrence of apoptosis/necrosis, the reduction
                      of the tetrazolium dye MTT to formazan and neutral red
                      uptake to prove cell viability, as well as synchrotron
                      infrared microscopy of single cells to evaluate possible
                      structural changes of DNA and nuclear proteins. The enhanced
                      photodamage observed in the presence of Pec@AgNP seems to
                      indicate that Rf enters into the cells complexed with the
                      nanoparticles.},
      cin          = {ICS-4},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29978491},
      UT           = {WOS:000450018200012},
      doi          = {10.1111/php.12974},
      url          = {https://juser.fz-juelich.de/record/857577},
}