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@ARTICLE{Helm:857582,
      author       = {Helm, Katharina and Viol, Kathrin and Weiger, Thomas Martin
                      and Tass, Peter A and Grefkes, Christian and del Monte,
                      Damir and Schiepek, Günter},
      title        = {{N}euronal connectivity in major depressive disorder: a
                      systematic review},
      journal      = {Neuropsychiatric disease and treatment},
      volume       = {Volume 14},
      issn         = {1178-2021},
      address      = {Albany, Auckland},
      publisher    = {Dove Medical Press},
      reportid     = {FZJ-2018-06567},
      pages        = {2715 - 2737},
      year         = {2018},
      abstract     = {Background: The causes of major depressive disorder (MDD),
                      as one of the most common psychiatric disorders, still
                      remain unclear. Neuroimaging has substantially contributed
                      to understanding the putative neuronal mechanisms underlying
                      depressed mood and motivational as well as cognitive
                      impairments in depressed individuals. In particular,
                      analyses addressing changes in interregional connectivity
                      seem to be a promising approach to capture the effects of
                      MDD at a systems level. However, a plethora of different,
                      sometimes contradicting results have been published so far,
                      making general conclusions difficult. Here we provide a
                      systematic overview about connectivity studies published in
                      the field over the last decade considering different
                      methodological as well as clinical issues.Methods: A
                      systematic review was conducted extracting neuronal
                      connectivity results from studies published between 2002 and
                      2015. The findings were summarized in tables and were
                      graphically visualized.Results: The review supports and
                      summarizes the notion of an altered fronto-limbic mood
                      regulation circuitry in MDD patients, but also stresses the
                      heterogeneity of the findings. The brain regions that are
                      most consistently affected across studies are the
                      orbitomedial prefrontal cortex, anterior cingulate cortex,
                      amygdala, hippocampus, cerebellum and the basal
                      ganglia.Conclusion: The results on connectivity in MDD are
                      very heterogeneous, partly due to different methods and
                      study designs, but also due to the temporal dynamics of
                      connectivity. While connectivity research is an important
                      step toward a complex systems approach to brain functioning,
                      future research should focus on the dynamics of functional
                      and effective connectivity.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30425491},
      UT           = {WOS:000447518000001},
      doi          = {10.2147/NDT.S170989},
      url          = {https://juser.fz-juelich.de/record/857582},
}