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000857606 037__ $$aFZJ-2018-06591
000857606 041__ $$aEnglish
000857606 1001_ $$0P:(DE-Juel1)168124$$aGutberlet, Thomas$$b0$$eCorresponding author
000857606 1112_ $$aMembranes Beyond - Int. Workshop on Status and Perspectives in Research on membrane Structure and Interaction$$cHamilton$$d2018-07-02 - 2018-07-04$$wCanada
000857606 245__ $$aDisturbed membranes – The influence of additives on local membrane structure and dynamics
000857606 260__ $$c2018
000857606 3367_ $$033$$2EndNote$$aConference Paper
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000857606 520__ $$aNowadays biological membranes are considered a flexible and dynamic matrix to separate individual cells and cell compartments and to host a multitude of molecules from phospholipids, sterols, proteins, surfactants or drugs. The main physical parameter related to the fluidity and flexibility of biological membranes is the main phase temperature where the surrounding lipid matrix is changing from a solid like gel state to a fluid like state. Individual membrane lipids exhibit very sharp phase transition temperatures which are easily modified by the addition of additives as cholesterol, surfactants, or other biological active molecules. To model biological membranes and their interaction with such molecules in a precices manner detailed knowledge on the local dynamics, clustering and phase separation  in the nanometer range is of general interest. Such dynamics can be probed by neutron and muon spectroscopy.Here we will show some examples of the influence of certain additives, in particular cholesterol and medium chain alcohols, on the local dynamics of phospholipid model membrane systems and the clustering and phase separation of such added molecules within the phospholipid membrane.
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000857606 65027 $$0V:(DE-MLZ)SciArea-160$$2V:(DE-HGF)$$aBiology$$x0
000857606 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and  Proteins$$x0
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000857606 7001_ $$0P:(DE-HGF)0$$aTrapp, Marcus$$b1
000857606 7001_ $$0P:(DE-HGF)0$$aPosselt, Dorthe$$b2
000857606 7001_ $$0P:(DE-HGF)0$$aPeters, Judith$$b3
000857606 7001_ $$0P:(DE-HGF)0$$aScheuermann, Robert$$b4
000857606 7001_ $$0P:(DE-HGF)0$$aMcKenzie, Ian$$b5
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000857606 9141_ $$y2018
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