TY  - CONF
AU  - Gutberlet, Thomas
AU  - Trapp, Marcus
AU  - Posselt, Dorthe
AU  - Peters, Judith
AU  - Scheuermann, Robert
AU  - McKenzie, Ian
TI  - Disturbed membranes – The influence of additives on local membrane structure and dynamics
M1  - FZJ-2018-06591
PY  - 2018
AB  - Nowadays biological membranes are considered a flexible and dynamic matrix to separate individual cells and cell compartments and to host a multitude of molecules from phospholipids, sterols, proteins, surfactants or drugs. The main physical parameter related to the fluidity and flexibility of biological membranes is the main phase temperature where the surrounding lipid matrix is changing from a solid like gel state to a fluid like state. Individual membrane lipids exhibit very sharp phase transition temperatures which are easily modified by the addition of additives as cholesterol, surfactants, or other biological active molecules. To model biological membranes and their interaction with such molecules in a precices manner detailed knowledge on the local dynamics, clustering and phase separation  in the nanometer range is of general interest. Such dynamics can be probed by neutron and muon spectroscopy.Here we will show some examples of the influence of certain additives, in particular cholesterol and medium chain alcohols, on the local dynamics of phospholipid model membrane systems and the clustering and phase separation of such added molecules within the phospholipid membrane.
T2  - Membranes Beyond - Int. Workshop on Status and Perspectives in Research on membrane Structure and Interaction
CY  - 2 Jul 2018 - 4 Jul 2018, Hamilton (Canada)
Y2  - 2 Jul 2018 - 4 Jul 2018
M2  - Hamilton, Canada
LB  - PUB:(DE-HGF)6
UR  - https://juser.fz-juelich.de/record/857606
ER  -