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@INPROCEEDINGS{Gutberlet:857606,
author = {Gutberlet, Thomas and Trapp, Marcus and Posselt, Dorthe and
Peters, Judith and Scheuermann, Robert and McKenzie, Ian},
title = {{D}isturbed membranes – {T}he influence of additives on
local membrane structure and dynamics},
reportid = {FZJ-2018-06591},
year = {2018},
abstract = {Nowadays biological membranes are considered a flexible and
dynamic matrix to separate individual cells and cell
compartments and to host a multitude of molecules from
phospholipids, sterols, proteins, surfactants or drugs. The
main physical parameter related to the fluidity and
flexibility of biological membranes is the main phase
temperature where the surrounding lipid matrix is changing
from a solid like gel state to a fluid like state.
Individual membrane lipids exhibit very sharp phase
transition temperatures which are easily modified by the
addition of additives as cholesterol, surfactants, or other
biological active molecules. To model biological membranes
and their interaction with such molecules in a precices
manner detailed knowledge on the local dynamics, clustering
and phase separation in the nanometer range is of general
interest. Such dynamics can be probed by neutron and muon
spectroscopy.Here we will show some examples of the
influence of certain additives, in particular cholesterol
and medium chain alcohols, on the local dynamics of
phospholipid model membrane systems and the clustering and
phase separation of such added molecules within the
phospholipid membrane.},
month = {Jul},
date = {2018-07-02},
organization = {Membranes Beyond - Int. Workshop on
Status and Perspectives in Research on
membrane Structure and Interaction,
Hamilton (Canada), 2 Jul 2018 - 4 Jul
2018},
subtyp = {After Call},
cin = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1 / JCNS-2},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)JCNS-2-20110106},
pnm = {6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)
/ 6G15 - FRM II / MLZ (POF3-6G15)},
pid = {G:(DE-HGF)POF3-6G4 / G:(DE-HGF)POF3-6G15},
experiment = {EXP:(DE-MLZ)SPHERES-20140101 /
EXP:(DE-MLZ)TOF-TOF-20140101},
typ = {PUB:(DE-HGF)6},
url = {https://juser.fz-juelich.de/record/857606},
}