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@ARTICLE{James:857706,
      author       = {James, Gregory M and Gryglewski, Gregor and Vanicek, Thomas
                      and Berroterán-Infante, Neydher and Philippe, Cécile and
                      Kautzky, Alexander and Nics, Lukas and Vraka, Chrysoula and
                      Godbersen, Godber M and Unterholzner, Jakob and
                      Sigurdardottir, Helen L and Spies, Marie and Seiger, René
                      and Kranz, Georg S and Hahn, Andreas and Mitterhauser,
                      Markus and Wadsak, Wolfgang and Bauer, Andreas and Hacker,
                      Marcus and Kasper, Siegfried and Lanzenberger, Rupert},
      title        = {{P}arcellation of the {H}uman {C}erebral {C}ortex {B}ased
                      on {M}olecular {T}argets in the {S}erotonin {S}ystem
                      {Q}uantified by {P}ositron {E}mission {T}omography {I}n
                      vivo},
      journal      = {Cerebral cortex},
      volume       = {1-11},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2018-06678},
      pages        = {11},
      year         = {2019},
      abstract     = {Parcellation of distinct areas in the cerebral cortex has a
                      long history in neuroscience and is of great value for the
                      study of brain function, specialization, and alterations in
                      neuropsychiatric disorders. Analysis of cytoarchitectonical
                      features has revealed their close association with molecular
                      profiles based on protein density. This provides a rationale
                      for the use of in vivo molecular imaging data for
                      parcellation of the cortex with the advantage of whole-brain
                      coverage. In the current work, parcellation was based on
                      expression of key players of the serotonin neurotransmitter
                      system. Positron emission tomography was carried out for the
                      quantification of serotonin 1A (5-HT1A, n = 30) and 5-HT2A
                      receptors (n = 22), the serotonin-degrading enzyme monoamine
                      oxidase A (MAO-A, n = 32) and the serotonin transporter
                      (5-HTT, n = 24) in healthy participants. Cortical protein
                      distribution maps were obtained using surface-based
                      quantification. Based on k-means clustering, silhouette
                      criterion and bootstrapping, five distinct clusters were
                      identified as the optimal solution. The defined clusters
                      proved of high explanatory value for the effects of
                      psychotropic drugs acting on the serotonin system, such as
                      antidepressants and psychedelics. Therefore, the proposed
                      method constitutes a sensible approach towards integration
                      of multimodal imaging data for research and development in
                      neuropharmacology and psychiatry. Key words: cortex,
                      cortical reconstruction, molecular imaging, parcellation,
                      PET, serotonin},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30357321},
      UT           = {WOS:000459518500028},
      doi          = {10.1093/cercor/bhy249},
      url          = {https://juser.fz-juelich.de/record/857706},
}