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@ARTICLE{Liao:857729,
      author       = {Liao, Yupeng and Oros-Peusquens, Ana-Maria and Lindemeyer,
                      Johannes and Lechea, Nazim and Weiß -Lucas, Carolin and
                      Langen, Karl-Josef and Shah, N. J.},
      title        = {{A}n {MR} technique for simultaneous quantitative imaging
                      of water content, conductivity and susceptibility, with
                      application to brain tumours using a 3{T} hybrid {MR}-{PET}
                      scanner},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2018-06697},
      pages        = {88},
      year         = {2019},
      abstract     = {Approaches for the quantitative mapping of water content,
                      electrical conductivity and susceptibility have been
                      developed independently. The purpose of this study is to
                      develop a method for simultaneously acquiring quantitative
                      water content, electrical conductivity and susceptibility
                      maps based on a 2D multi-echo gradient echo sequence.
                      Another purpose is to investigate the changes in these
                      properties caused by brain tumours. This was done using a 3T
                      hybrid magnetic resonance imaging and positron emission
                      tomography (MR-PET) scanner. Water content maps were derived
                      after performing T2* and transmit-receive field bias
                      corrections to magnitude images essentially reflecting only
                      the H2O content contrast. Phase evolution during the
                      multi-echo train was used to generate field maps and derive
                      quantitative susceptibility, while the conductivity maps
                      were retrieved from the phase value at zero echo time.
                      Performance of the method is demonstrated on phantoms and
                      two healthy volunteers. In addition, the method was applied
                      to three patients with brain tumours and a comparison to
                      maps obtained from PET using
                      O-(2-[18 F]fluoroethyl)-L-tyrosine and clinical MR images
                      is presented. The combined information of the water content,
                      conductivity and susceptibility may provide additional
                      information about the tissue viability. Future studies can
                      benefit from the evaluation of these contrasts with
                      shortened acquisition times.},
      cin          = {INM-4 / JARA-BRAIN},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30643159},
      UT           = {WOS:000455592300009},
      doi          = {10.1038/s41598-018-36435-8},
      url          = {https://juser.fz-juelich.de/record/857729},
}