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@ARTICLE{Panwalkar:857872,
      author       = {Panwalkar, Vineet and Neudecker, Philipp and Willbold,
                      Dieter and Dingley, Andrew J.},
      title        = {{M}ultiple {WW} domains of {N}edd4-1 undergo conformational
                      exchange that is quenched upon peptide binding},
      journal      = {FEBS letters},
      volume       = {591},
      number       = {11},
      issn         = {0014-5793},
      address      = {Chichester},
      publisher    = {Wiley},
      reportid     = {FZJ-2018-06835},
      pages        = {1573 - 1583},
      year         = {2017},
      abstract     = {The third WW domain (WW3*) of the ubiquitin ligase human
                      neuronal precursor cell expressed developmentally
                      downregulated gene 4-1 (hNedd4-1) was reported to bind its
                      PY motif peptide by a coupled folding-binding equilibrium.
                      However, it is unknown whether these thermodynamic
                      properties are retained in the context of neighboring
                      hNedd4-1 domains. In this report, NMR data show that the
                      WW3* displays a fold-unfold equilibrium in the presence of
                      neighboring WW domains, and that similar fold-unfold
                      equilibria also likely exist for neighboring WW domains.
                      These equilibria are quenched upon interaction with peptide.
                      Thus, the binding mechanism of hNedd4-1 WW domains to
                      proteins involves coupled folding and binding equilibria,
                      and this mechanism may be a general feature that modulates
                      peptide affinities of WW domains.},
      cin          = {ICS-6},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621)},
      pid          = {G:(DE-HGF)POF3-6215},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:28471472},
      UT           = {WOS:000403354400009},
      doi          = {10.1002/1873-3468.12664},
      url          = {https://juser.fz-juelich.de/record/857872},
}