Home > Publications database > Peptide model systems: Correlation between thermophilicity and hydrophilicity > print

001     858228
005     20240619083548.0
024 7 _ |a 10.1063/1.5042051
|2 doi
024 7 _ |a 0021-9606
|2 ISSN
024 7 _ |a 1089-7690
|2 ISSN
024 7 _ |a 1520-9032
|2 ISSN
024 7 _ |a 2128/20977
|2 Handle
024 7 _ |a pmid:30068171
|2 pmid
024 7 _ |a WOS:000440586200041
|2 WOS
024 7 _ |a altmetric:45950592
|2 altmetric
037 _ _ |a FZJ-2018-07128
082 _ _ |a 530
100 1 _ |a Niether, Doreen
|0 P:(DE-Juel1)166572
|b 0
|u fzj
245 _ _ |a Peptide model systems: Correlation between thermophilicity and hydrophilicity
260 _ _ |a Melville, NY
|c 2018
|b American Institute of Physics
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1545202066_14845
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a In recent years, the response of biomolecules to a temperature gradient has been utilized to monitor reactions of biomolecules, but the underlying mechanism is not well understood due to the complexity of the multicomponent system. To identify some underlying principles, we investigate the thermal diffusion of small amide molecules in water systematically. We re-analyze previous measurements of urea and formamide and compare the results with acetamide, N-methylformamide, and N, N-dimethylformamide, amides with a lower hydrophilicity. It turns out that less hydrophilic substances do not show the typical temperature dependence of water soluble macromolecules. Analyzing temperature and concentration dependent measurements using an empirical expression originally derived for nonpolar mixtures, we find that the so-called isotope contribution depends strongly on the hydrophilicity of the solute. This can be qualitatively understood by comparing with molecular dynamic simulations of Lennard-Jones fluids. The hydrophobic/hydrophilic balance also influences the structure in the fluid and with that the thermal expansion coefficient, which correlates with the thermal diffusion coefficient. Furthermore, we observe a clear correlation of the temperature and concentration dependence of the Soret coefficient with the hydrophilicity, which can be quantitatively described by the partition coefficient log P
536 _ _ |a 551 - Functional Macromolecules and Complexes (POF3-551)
|0 G:(DE-HGF)POF3-551
|c POF3-551
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef
700 1 _ |a Kriegs, Hartmut
|0 P:(DE-Juel1)130773
|b 1
700 1 _ |a Dhont, Jan K. G.
|0 P:(DE-Juel1)130616
|b 2
700 1 _ |a Wiegand, Simone
|0 P:(DE-Juel1)131034
|b 3
|e Corresponding author
773 _ _ |a 10.1063/1.5042051
|g Vol. 149, no. 4, p. 044506 -
|0 PERI:(DE-600)1473050-9
|n 4
|p 044506 -
|t The journal of chemical physics
|v 149
|y 2018
|x 1089-7690
856 4 _ |u https://juser.fz-juelich.de/record/858228/files/supplementary-01.pdf
|y Restricted
856 4 _ |y Published on 2018-07-30. Available in OpenAccess from 2019-07-30.
|u https://juser.fz-juelich.de/record/858228/files/1.5042051.pdf
856 4 _ |y Published on 2018-07-30. Available in OpenAccess from 2019-07-30.
|u https://juser.fz-juelich.de/record/858228/files/amide018-asub-002.pdf
856 4 _ |x pdfa
|u https://juser.fz-juelich.de/record/858228/files/supplementary-01.pdf?subformat=pdfa
|y Restricted
856 4 _ |y Published on 2018-07-30. Available in OpenAccess from 2019-07-30.
|x pdfa
|u https://juser.fz-juelich.de/record/858228/files/amide018-asub-002.pdf?subformat=pdfa
856 4 _ |y Published on 2018-07-30. Available in OpenAccess from 2019-07-30.
|x pdfa
|u https://juser.fz-juelich.de/record/858228/files/1.5042051.pdf?subformat=pdfa
909 C O |o oai:juser.fz-juelich.de:858228
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 0
|6 P:(DE-Juel1)166572
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 1
|6 P:(DE-Juel1)130773
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 2
|6 P:(DE-Juel1)130616
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 3
|6 P:(DE-Juel1)131034
913 1 _ |a DE-HGF
|b Key Technologies
|l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences
|1 G:(DE-HGF)POF3-550
|0 G:(DE-HGF)POF3-551
|2 G:(DE-HGF)POF3-500
|v Functional Macromolecules and Complexes
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2018
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0600
|2 StatID
|b Ebsco Academic Search
915 _ _ |a Embargoed OpenAccess
|0 StatID:(DE-HGF)0530
|2 StatID
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b J CHEM PHYS : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a WoS
|0 StatID:(DE-HGF)0110
|2 StatID
|b Science Citation Index
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b ASC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a National-Konsortium
|0 StatID:(DE-HGF)0430
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0320
|2 StatID
|b PubMed Central
915 _ _ |a Nationallizenz
|0 StatID:(DE-HGF)0420
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)ICS-3-20110106
|k ICS-3
|l Weiche Materie
|x 0
980 1 _ |a FullTexts
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)ICS-3-20110106

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21