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@ARTICLE{Zhang:858253,
      author       = {Zhang, Ke and Huang, Dengfeng and Shah, N. J.},
      title        = {{C}omparison of {R}esting-{S}tate {B}rain {A}ctivation
                      {D}etected by {BOLD}, {B}lood {V}olume and {B}lood {F}low},
      journal      = {Frontiers in human neuroscience},
      volume       = {12},
      issn         = {1662-5161},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2018-07152},
      pages        = {443},
      year         = {2018},
      abstract     = {Resting-state brain activity has been widely investigated
                      using blood oxygenation level dependent (BOLD) contrast
                      techniques. However, BOLD signal changes reflect a
                      combination of the effects of cerebral blood flow (CBF),
                      cerebral blood volume (CBV), as well as the cerebral
                      metabolic rate of oxygen (CMRO2). In this study,
                      resting-state brain activation was detected and compared
                      using the following techniques: (a) BOLD, using a
                      gradient-echo echo planar imaging (GE-EPI) sequence; (b)
                      CBV-weighted signal, acquired using gradient and spin echo
                      (GRASE) based vascular space occupancy (VASO); and (c) CBF,
                      using pseudo-continuous arterial spin labeling (pCASL).
                      Reliable brain networks were detected using VASO and ASL,
                      including sensorimotor, auditory, primary visual, higher
                      visual, default mode, salience and left/right executive
                      control networks. Differences between the resting-state
                      activation detected with ASL, VASO and BOLD could
                      potentially be due to the different temporal signal-to-noise
                      ratio (tSNR) and the short post-labeling delay (PLD) in ASL,
                      along with differences in the spin-echo readout of VASO. It
                      is also possible that the dynamics of spontaneous
                      fluctuations in BOLD, CBV and CBF could differ due to
                      biological reasons, according to their location within the
                      brain.},
      cin          = {INM-4 / JARA-BRAIN / INM-11},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-11-20170113},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30467468},
      UT           = {WOS:000449612900001},
      doi          = {10.3389/fnhum.2018.00443},
      url          = {https://juser.fz-juelich.de/record/858253},
}