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| Hauptseite > Publikationsdatenbank > Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins > print |
| Hauptseite > Publikationsdatenbank > Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins > print |
| 001 | 858403 | ||
| 005 | 20210129235940.0 | ||
| 024 | 7 | _ | |a 10.1016/j.compchemeng.2018.02.013 |2 doi |
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| 100 | 1 | _ | |a Orr, Asuka A. |0 0000-0003-4628-526X |b 0 |
| 245 | _ | _ | |a Elucidating the multi-targeted anti-amyloid activity and enhanced islet amyloid polypeptide binding of β-wrapins |
| 260 | _ | _ | |a Amsterdam [u.a.] |c 2018 |b Elsevier Science |
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| 520 | _ | _ | |a β-wrapins are engineered binding proteins stabilizing the β-hairpin conformations of amyloidogenic proteins islet amyloid polypeptide (IAPP), amyloid-β, and α-synuclein, thus inhibiting their amyloid propensity. Here, we use computational and experimental methods to investigate the molecular recognition of IAPP by β-wrapins. We show that the multi-targeted, IAPP, amyloid-β, and α-synuclein, binding properties of β-wrapins originate mainly from optimized interactions between β-wrapin residues and sets of residues in the three amyloidogenic proteins with similar physicochemical properties. Our results suggest that IAPP is a comparatively promiscuous β-wrapin target, probably due to the low number of charged residues in the IAPP β-hairpin motif. The sub-micromolar affinity of β-wrapin HI18, specifically selected against IAPP, is achieved in part by salt-bridge formation between HI18 residue Glu10 and the IAPP N-terminal residue Lys1, both located in the flexible N-termini of the interacting proteins. Our findings provide insights towards developing novel protein-based single- or multi-targeted therapeutics. |
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| 700 | 1 | _ | |a Shaykhalishahi, Hamed |0 P:(DE-Juel1)167315 |b 1 |
| 700 | 1 | _ | |a Mirecka, Ewa A. |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Jonnalagadda, Sai Vamshi R. |0 0000-0001-7327-238X |b 3 |
| 700 | 1 | _ | |a Hoyer, Wolfgang |0 P:(DE-Juel1)166306 |b 4 |e Corresponding author |
| 700 | 1 | _ | |a Tamamis, Phanourios |0 0000-0002-3342-2651 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1016/j.compchemeng.2018.02.013 |g Vol. 116, p. 322 - 332 |0 PERI:(DE-600)1499971-7 |p 322 - 332 |t Computers & chemical engineering |v 116 |y 2018 |x 0098-1354 |
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