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@INBOOK{Ermert:858406,
      author       = {Ermert, Johannes and Neumaier, Bernd},
      title        = {{C}hapter 20, {P}art {E}: {R}adiotracers for {PET} and
                      {MR}-{PET} {I}maging},
      address      = {Cambridge},
      publisher    = {Royal Society of Chemistry},
      reportid     = {FZJ-2018-07292},
      isbn         = {978-1-78801-074-0},
      series       = {New Developments in NMR},
      pages        = {381-399},
      year         = {2018},
      comment      = {-Hybrid MR-PET Imaging: Systems, Methods and Applications /
                      Shah, N Jon (Editor); Cambridge : Royal Society of
                      Chemistry, 2018, ; ISBN: ; doi:10.1039/9781788013062},
      booktitle     = {-Hybrid MR-PET Imaging: Systems,
                       Methods and Applications / Shah, N Jon
                       (Editor); Cambridge : Royal Society of
                       Chemistry, 2018, ; ISBN: ;
                       doi:10.1039/9781788013062},
      abstract     = {Positron emission tomography (PET) combined with magnetic
                      resonance (MR) is a rapidly expanding imaging modality. For
                      this application, the availability of radiotracers labelled
                      with positron emitters is a basic requirement. These
                      short-lived neutron deficient positron emitters are produced
                      at a cyclotron. In a cyclotron, charged particles are
                      accelerated up to energies enabling to overcome Coulomb
                      repulsion and induce nuclear reactions. The beam is
                      extracted to target systems containing stable isotopes. Due
                      to the bombardment, these stable isotopes are converted via
                      nuclear reactions into radionuclides. The positron emitters
                      are subsequently used for radiolabelling molecules to obtain
                      radiotracers for various applications. Usually
                      radiosyntheses are carried out in automated synthesis
                      modules. The relatively short physical half-life of the
                      positron emitters in use requires fast and efficient
                      radiolabelling strategies that have been optimised for the
                      most common radiopharmaceuticals in order to facilitate
                      robust tracer production in sufficient activity amounts.
                      Beside the PET alone approach, emerging methods deal with
                      simultaneous PET-MR imaging to combine the high sensitivity
                      of PET with the high resolution of MR. One possibility to
                      exploit the synergy of both techniques is the combination of
                      clinically established paramagnetic contrast agents and
                      radiopharmaceuticals. This method was studied in several
                      preclinical and clinical studies. A much more elegant
                      possibility is the introduction of both modalities in one
                      single, bimodal contrast and positron-emitting probe. Thus
                      far, this technique was only tested in preclinical set-ups.},
      cin          = {INM-5 / INM-4 / INM-11 / JARA-BRAIN},
      cid          = {I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-11-20170113 / $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)7},
      url          = {https://juser.fz-juelich.de/record/858406},
}