%0 Journal Article
%A Liu, Yang
%A Kurtán, Tibor
%A Mándi, Attila
%A Weber, Horst
%A Wang, Changyun
%A Hartmann, Rudolf
%A Lin, Wenhan
%A Daletos, Georgios
%A Proksch, Peter
%T A novel 10-membered macrocyclic lactone from the mangrove-derived endophytic fungus Annulohypoxylon sp.
%J Tetrahedron letters
%V 59
%N 7
%@ 0040-4039
%C Amsterdam [u.a.]
%I Elsevier Science
%M FZJ-2018-07357
%P 632 - 636
%D 2018
%X A novel 10-membered macrolactone, hypoxylide (1), was isolated from the endophytic fungus Annulohypoxylon sp. that was obtained from the Mangrove plant Rhizophora racemosa. The structure and absolute configuration of 1 were unambiguously elucidated by comprehensive 1D and 2D NMR, as well as by HRESIMS and ECD spectroscopic analyses. Hypoxylide (1) features an unprecedented polyketide skeleton comprised of a trihydroxynaphthalene-dione moiety fused to a decalactone ring. A plausible biosynthetic pathway of this novel metabolite is proposed.
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000424717600012
%R 10.1016/j.tetlet.2018.01.001
%U https://juser.fz-juelich.de/record/858485