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@ARTICLE{Wang:858486,
      author       = {Wang, Hao and Eze, Peter M. and Höfert, Simon-Patrick and
                      Janiak, Christoph and Hartmann, Rudolf and Okoye, Festus B.
                      C. and Esimone, Charles O. and Orfali, Raha S. and Dai,
                      Haofu and Liu, Zhen and Proksch, Peter},
      title        = {{S}ubstituted l -tryptophan- l -phenyllactic acid
                      conjugates produced by an endophytic fungus {A}spergillus
                      aculeatus using an {OSMAC} approach},
      journal      = {RSC Advances},
      volume       = {8},
      number       = {14},
      issn         = {2046-2069},
      address      = {London},
      publisher    = {RSC Publishing},
      reportid     = {FZJ-2018-07358},
      pages        = {7863 - 7872},
      year         = {2018},
      abstract     = {The endophytic fungus Aspergillus aculeatus isolated from
                      leaves of the papaya plant Carica papaya was fermented on
                      solid rice medium, yielding a new
                      L-tryptophan-L-phenyllactic acid conjugate (1) and thirteen
                      known compounds (11, 14–25). In addition, an OSMAC
                      approach was employed by adding eight different sodium or
                      ammonium salts to the rice medium. Addition of $3.5\%$ NaNO3
                      caused a significant change of the metabolite pattern of the
                      fungus as indicated by HPLC analysis. Subsequent isolation
                      yielded several new substituted L-tryptophan-L-phenyllactic
                      acid conjugates (1–10) in addition to three known
                      compounds (11–13), among which compounds 2–10, 12–13
                      were not detected in the rice control culture. All
                      structures were unambiguously elucidated by one and two
                      dimensional NMR spectroscopy and by mass spectrometry. The
                      absolute configuration of the new compounds was determined
                      by Marfey's reaction and X-ray single crystal diffraction.
                      Compounds 19–22 showed cytotoxicity against the L5178Y
                      mouse lymphoma cell line with IC50 values of 3.4, 1.4, 7.3
                      and 23.7 μM, respectively.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000425647000062},
      doi          = {10.1039/C8RA00200B},
      url          = {https://juser.fz-juelich.de/record/858486},
}