001     858486
005     20210129235959.0
024 7 _ |a 10.1039/C8RA00200B
|2 doi
024 7 _ |a 2128/20792
|2 Handle
024 7 _ |a WOS:000425647000062
|2 WOS
037 _ _ |a FZJ-2018-07358
082 _ _ |a 540
100 1 _ |a Wang, Hao
|0 P:(DE-HGF)0
|b 0
245 _ _ |a Substituted l -tryptophan- l -phenyllactic acid conjugates produced by an endophytic fungus Aspergillus aculeatus using an OSMAC approach
260 _ _ |a London
|c 2018
|b RSC Publishing
336 7 _ |a article
|2 DRIVER
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1544880294_23471
|2 PUB:(DE-HGF)
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a Journal Article
|0 0
|2 EndNote
520 _ _ |a The endophytic fungus Aspergillus aculeatus isolated from leaves of the papaya plant Carica papaya was fermented on solid rice medium, yielding a new L-tryptophan-L-phenyllactic acid conjugate (1) and thirteen known compounds (11, 14–25). In addition, an OSMAC approach was employed by adding eight different sodium or ammonium salts to the rice medium. Addition of 3.5% NaNO3 caused a significant change of the metabolite pattern of the fungus as indicated by HPLC analysis. Subsequent isolation yielded several new substituted L-tryptophan-L-phenyllactic acid conjugates (1–10) in addition to three known compounds (11–13), among which compounds 2–10, 12–13 were not detected in the rice control culture. All structures were unambiguously elucidated by one and two dimensional NMR spectroscopy and by mass spectrometry. The absolute configuration of the new compounds was determined by Marfey's reaction and X-ray single crystal diffraction. Compounds 19–22 showed cytotoxicity against the L5178Y mouse lymphoma cell line with IC50 values of 3.4, 1.4, 7.3 and 23.7 μM, respectively.
536 _ _ |a 551 - Functional Macromolecules and Complexes (POF3-551)
|0 G:(DE-HGF)POF3-551
|c POF3-551
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef
700 1 _ |a Eze, Peter M.
|0 0000-0002-3777-0450
|b 1
700 1 _ |a Höfert, Simon-Patrick
|0 P:(DE-HGF)0
|b 2
700 1 _ |a Janiak, Christoph
|0 0000-0002-6288-9605
|b 3
700 1 _ |a Hartmann, Rudolf
|0 P:(DE-Juel1)132001
|b 4
|u fzj
700 1 _ |a Okoye, Festus B. C.
|0 P:(DE-HGF)0
|b 5
700 1 _ |a Esimone, Charles O.
|0 P:(DE-HGF)0
|b 6
700 1 _ |a Orfali, Raha S.
|0 P:(DE-HGF)0
|b 7
700 1 _ |a Dai, Haofu
|0 0000-0002-4284-1276
|b 8
700 1 _ |a Liu, Zhen
|0 0000-0003-3314-7853
|b 9
700 1 _ |a Proksch, Peter
|0 P:(DE-HGF)0
|b 10
|e Corresponding author
773 _ _ |a 10.1039/C8RA00200B
|g Vol. 8, no. 14, p. 7863 - 7872
|0 PERI:(DE-600)2623224-8
|n 14
|p 7863 - 7872
|t RSC Advances
|v 8
|y 2018
|x 2046-2069
856 4 _ |y OpenAccess
|u https://juser.fz-juelich.de/record/858486/files/Substituted%20L-tryptophan-L-phenyllactic%20acid%20conjugates%20produced%20by%20an%20endophytic%20fungus%20Aspergillus%20aculeatus%20using%20an%20OSMAC%20approach_2018.pdf
856 4 _ |y OpenAccess
|x pdfa
|u https://juser.fz-juelich.de/record/858486/files/Substituted%20L-tryptophan-L-phenyllactic%20acid%20conjugates%20produced%20by%20an%20endophytic%20fungus%20Aspergillus%20aculeatus%20using%20an%20OSMAC%20approach_2018.pdf?subformat=pdfa
909 C O |o oai:juser.fz-juelich.de:858486
|p openaire
|p open_access
|p VDB
|p driver
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich
|0 I:(DE-588b)5008462-8
|k FZJ
|b 4
|6 P:(DE-Juel1)132001
913 1 _ |a DE-HGF
|b Key Technologies
|l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences
|1 G:(DE-HGF)POF3-550
|0 G:(DE-HGF)POF3-551
|2 G:(DE-HGF)POF3-500
|v Functional Macromolecules and Complexes
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2018
915 _ _ |a Creative Commons Attribution CC BY 3.0
|0 LIC:(DE-HGF)CCBY3
|2 HGFVOC
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b RSC ADV : 2017
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0501
|2 StatID
|b DOAJ Seal
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a Peer Review
|0 StatID:(DE-HGF)0030
|2 StatID
|b DOAJ : Blind peer review
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1150
|2 StatID
|b Current Contents - Physical, Chemical and Earth Sciences
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a National-Konsortium
|0 StatID:(DE-HGF)0430
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Clarivate Analytics Master Journal List
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)ICS-6-20110106
|k ICS-6
|l Strukturbiochemie
|x 0
980 1 _ |a FullTexts
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)ICS-6-20110106
981 _ _ |a I:(DE-Juel1)IBI-7-20200312


LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21