TY  - JOUR
AU  - Ancheeva, Elena
AU  - Mándi, Attila
AU  - Király, Sándor B.
AU  - Kurtán, Tibor
AU  - Hartmann, Rudolf
AU  - Akone, Sergi H.
AU  - Weber, Horst
AU  - Daletos, Georgios
AU  - Proksch, Peter
TI  - Chaetolines A and B, Pyrano[3,2- f ]isoquinoline Alkaloids from Cultivation of Chaetomium sp. in the Presence of Autoclaved Pseudomonas aeruginosa
JO  - Journal of natural products
VL  - 81
IS  - 11
SN  - 1520-6025
CY  - Washington, DC
PB  - Soc.
M1  - FZJ-2018-07359
SP  - 2392 - 2398
PY  - 2018
AB  - The first members of a new alkaloid class, chaetolines A (1) and B (2), which feature a pyrano[3,2-f]isoquinoline core structure, were obtained from a crude extract of the fungal endophyte Chaetomium sp. after cultivation in the presence of autoclaved Pseudomonas aeruginosa. The structures of the new compounds, including the absolute configuration of the major stereoisomer, were determined through detailed analysis of HRESIMS, 1D/2D NMR, and calculation of ECD data. The possible biosynthetic origin of the unprecedented scaffold of 1 and 2 is proposed. The current study provides further evidence for mixed fermentation as a powerful tool to induce the accumulation of cryptic fungal natural products even in the absence of viable bacterial cells.
LB  - PUB:(DE-HGF)16
C6  - pmid:30343566
UR  - <Go to ISI:>//WOS:000451496100009
DO  - DOI:10.1021/acs.jnatprod.8b00373
UR  - https://juser.fz-juelich.de/record/858487
ER  -