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@ARTICLE{Aschenbrenner:858528,
author = {Aschenbrenner, Jennifer and Marx, Patrick and Pietruszka,
Jörg and Marienhagen, Jan},
title = {{M}icrobial production of natural and non‐natural
monolignols with {E}scherichia coli},
journal = {ChemBioChem},
volume = {20},
number = {7},
issn = {1439-7633},
address = {Weinheim},
publisher = {Wiley-VCH},
reportid = {FZJ-2018-07399},
pages = {949-954},
year = {2019},
note = {Biotechnologie 1},
abstract = {Phenylpropanoids and phenylpropanoid‐derived plant
polyphenols find numerous applications in the food and
pharmaceutical industries. In recent years, several
microbial platform organisms have been engineered towards
producing such compounds. However, for the most part,
microbial (poly)phenol production is inspired by nature, so
naturally occurring compounds have predominantly been
produced to date.Here we have taken advantage of the
promiscuity of the enzymes involved in phenylpropanoid
synthesis and exploited the versatility of an engineered
Escherichia coli strain harboring a synthetic monolignol
pathway to convert supplemented natural and unnatural
phenylpropenoic acids into their corresponding monolignols.
The performed biotransformations showed that this strain is
able to catalyze the stepwise reduction of chemically
interesting unnatural phenylpropenoic acids such as
3,4,5‐trimethoxycinnamic acid, 5‐bromoferulic acid,
2‐nitroferulic acid, and a “bicyclic” p‐coumaric
acid derivative, in addition to six naturally occurring
phenylpropenoic acids.},
cin = {IBG-1 / IBOC},
ddc = {540},
cid = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)IBOC-20090406},
pnm = {583 - Innovative Synergisms (POF3-583)},
pid = {G:(DE-HGF)POF3-583},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30537293},
UT = {WOS:000462914700013},
doi = {10.1002/cbic.201800673},
url = {https://juser.fz-juelich.de/record/858528},
}