000858558 001__ 858558
000858558 005__ 20240619091240.0
000858558 0247_ $$2doi$$a10.1002/jbm.a.36363
000858558 0247_ $$2ISSN$$a1549-3296
000858558 0247_ $$2ISSN$$a1552-4965
000858558 0247_ $$2pmid$$apmid:29427541
000858558 0247_ $$2WOS$$aWOS:000431004500017
000858558 0247_ $$2altmetric$$aaltmetric:33086646
000858558 037__ $$aFZJ-2018-07428
000858558 082__ $$a570
000858558 1001_ $$0P:(DE-Juel1)164336$$aBelu, Andreea$$b0
000858558 245__ $$aAsymmetric, nano-textured surfaces influence neuron viability and polarity
000858558 260__ $$aNew York, NY [u.a.]$$bWiley64698$$c2018
000858558 3367_ $$2DRIVER$$aarticle
000858558 3367_ $$2DataCite$$aOutput Types/Journal article
000858558 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1545052478_24403
000858558 3367_ $$2BibTeX$$aARTICLE
000858558 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000858558 3367_ $$00$$2EndNote$$aJournal Article
000858558 520__ $$aThree dimensional, nanostructured surfaces have attracted considerable attention in biomedical research since they have proven to represent a powerful platform to influence cell fate. In particular, nanorods and nanopillars possess great potential for the control of cell adhesion and differentiation, gene and biomolecule delivery, optical and electrical stimulation and recording, as well as cell patterning. Here, we investigate the influence of asymmetric poly(dichloro‐p‐xylene) (PPX) columnar films on the adhesion and maturation of cortical neurons. We show that nanostructured films with dense, inclined polymer columns can support viable primary neuronal culture. The cell‐nanostructure interface is characterized showing a minimal cell penetration but strong adhesion on the surface. Moreover, we quantify the influence of the nano‐textured surface on the neural development (soma size, neuritogenesis, and polarity) in comparison to a planar PPX sample. We demonstrate that the nanostructures facilitates an enhancement in neurite branching as well as elongation of axons and growth cones. Furthermore, we show for the first time that the asymmetric orientation of polymeric nanocolumns strongly influences the initiation direction of the axon formation. These results evidence that 3D nano‐topographies can significantly change neural development and can be used to engineer axon elongation
000858558 536__ $$0G:(DE-HGF)POF3-552$$a552 - Engineering Cell Function (POF3-552)$$cPOF3-552$$fPOF III$$x0
000858558 588__ $$aDataset connected to CrossRef
000858558 7001_ $$0P:(DE-HGF)0$$aYilmaz, Mehmet$$b1
000858558 7001_ $$0P:(DE-Juel1)156529$$aNeumann, Elmar$$b2$$ufzj
000858558 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b3
000858558 7001_ $$0P:(DE-HGF)0$$aDemirel, Gokhan$$b4
000858558 7001_ $$0P:(DE-Juel1)128707$$aMayer, Dirk$$b5$$eCorresponding author
000858558 773__ $$0PERI:(DE-600)1477192-5$$a10.1002/jbm.a.36363$$gVol. 106, no. 6, p. 1634 - 1645$$n6$$p1634 - 1645$$tJournal of biomedical materials research / A A$$v106$$x1549-3296$$y2018
000858558 909CO $$ooai:juser.fz-juelich.de:858558$$pVDB
000858558 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)164336$$aForschungszentrum Jülich$$b0$$kFZJ
000858558 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)164336$$a ICS-8$$b0
000858558 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)156529$$aForschungszentrum Jülich$$b2$$kFZJ
000858558 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128713$$aForschungszentrum Jülich$$b3$$kFZJ
000858558 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128707$$aForschungszentrum Jülich$$b5$$kFZJ
000858558 9131_ $$0G:(DE-HGF)POF3-552$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vEngineering Cell Function$$x0
000858558 9141_ $$y2018
000858558 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000858558 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000858558 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000858558 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000858558 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000858558 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000858558 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000858558 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000858558 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000858558 920__ $$lyes
000858558 9201_ $$0I:(DE-Juel1)ICS-8-20110106$$kICS-8$$lBioelektronik$$x0
000858558 980__ $$ajournal
000858558 980__ $$aVDB
000858558 980__ $$aI:(DE-Juel1)ICS-8-20110106
000858558 980__ $$aUNRESTRICTED
000858558 981__ $$aI:(DE-Juel1)IBI-3-20200312