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@ARTICLE{Belu:858558,
      author       = {Belu, Andreea and Yilmaz, Mehmet and Neumann, Elmar and
                      Offenhäusser, Andreas and Demirel, Gokhan and Mayer, Dirk},
      title        = {{A}symmetric, nano-textured surfaces influence neuron
                      viability and polarity},
      journal      = {Journal of biomedical materials research / A A},
      volume       = {106},
      number       = {6},
      issn         = {1549-3296},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley64698},
      reportid     = {FZJ-2018-07428},
      pages        = {1634 - 1645},
      year         = {2018},
      abstract     = {Three dimensional, nanostructured surfaces have attracted
                      considerable attention in biomedical research since they
                      have proven to represent a powerful platform to influence
                      cell fate. In particular, nanorods and nanopillars possess
                      great potential for the control of cell adhesion and
                      differentiation, gene and biomolecule delivery, optical and
                      electrical stimulation and recording, as well as cell
                      patterning. Here, we investigate the influence of asymmetric
                      poly(dichloro‐p‐xylene) (PPX) columnar films on the
                      adhesion and maturation of cortical neurons. We show that
                      nanostructured films with dense, inclined polymer columns
                      can support viable primary neuronal culture. The
                      cell‐nanostructure interface is characterized showing a
                      minimal cell penetration but strong adhesion on the surface.
                      Moreover, we quantify the influence of the nano‐textured
                      surface on the neural development (soma size,
                      neuritogenesis, and polarity) in comparison to a planar PPX
                      sample. We demonstrate that the nanostructures facilitates
                      an enhancement in neurite branching as well as elongation of
                      axons and growth cones. Furthermore, we show for the first
                      time that the asymmetric orientation of polymeric
                      nanocolumns strongly influences the initiation direction of
                      the axon formation. These results evidence that 3D
                      nano‐topographies can significantly change neural
                      development and can be used to engineer axon elongation},
      cin          = {ICS-8},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-8-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29427541},
      UT           = {WOS:000431004500017},
      doi          = {10.1002/jbm.a.36363},
      url          = {https://juser.fz-juelich.de/record/858558},
}