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100 1 _ |a Grasmik, Viktoria
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245 _ _ |a Synthesis and biological characterization of alloyed silver–platinum nanoparticles: from compact core–shell nanoparticles to hollow nanoalloys
260 _ _ |a London
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520 _ _ |a Bimetallic nanoparticles consisting of silver and platinum were prepared by a modified seeded-growth process in water in the full composition range in steps of 10 mol%. The particles had diameters between 15–25 nm as determined by disc centrifugal sedimentation (DCS) and transmission electron microscopy (TEM). Whereas particles with high platinum content were mostly spherical with a solid silver core/platinum shell structure, mostly hollow alloyed nanoparticles were observed with increasing silver content. The internal structure and the elemental distribution within the particles were elucidated by high-resolution transmission electron microscopy (HRTEM) in combination with energy-dispersive X-ray spectroscopy (EDX). The particles were cytotoxic for human mesenchymal stem cells (hMSC) above 50 mol% silver. This was explained by dissolution experiments where silver was only released at and above 50 mol% silver. In contrast, platinum-rich particles (less than 50 mol% silver) did not release any silver ions. This indicates that the presence of platinum inhibits the oxidative dissolution of silver.
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700 1 _ |a Breisch, Marina
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700 1 _ |a Loza, Kateryna
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700 1 _ |a Heggen, Marc
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700 1 _ |a Köller, Manfred
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700 1 _ |a Sengstock, Christina
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700 1 _ |a Epple, Matthias
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773 _ _ |a 10.1039/C8RA06461J
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